Research Tools

Displaying 1 - 10 of 71


A Novel Organs-On-Chip Platform

Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both controlled by the intelligent use of a computer-operated system of pumps and valves. This permits, for the first time, a compact, low-cost system for creating a time-dependent drug dosage profile in a tissue system inside each well.


Licensing Contact

Ashok Choudhury

615.322.2503

Improved Biomanufacturing Using Biological Clock Control for High Yield/Low Cost Bioproduct

A team of researchers at Vanderbilt University has developed a method of manipulating the circadian clock of cyanobacteria. This biological manipulation is used to increase gene expression in target genes that produce biofuel and high-value bioproducts, such as pharmaceuticals and cosmetics from precursor-expressing genes. Altering the circadian rhythm in the bacteria provides an improved approach to bioproduct development on a large scale using sunlight as a zero--cost energy solution.


Licensing Contact

Masood Machingal

615.343.3548

Agriculture: Control of Insect Populations via Wolbachia or Bacteriophage Tools

The insect microbiome is a rich resource that can explored to control insect reproduction and insect populations at large. Vanderbilt University has a collection of technologies available for such purposes, including bacteriophage therapies, Wolbachia genomic editing techniques and tools, and transgenic insect approaches.


Licensing Contact

Jody Hankins

615.322.5907

Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

A research team at Vanderbilt University Mass Spectrometry Research Center has developed the Molecular Image Fusion software system, that by fusing spatial correspondence between histology and imaging mass spectrometry (IMS) measurements and cross-modality modeling, can predict ion distributions in tissue at spatial resolutions that exceed their acquisition resolution. The prediction resolution can even exceed the highest spatial resolution at which IMS can be physically measured. This software has been successfully tested on different IMS datasets and can be extended to other imaging modalities like MRI, PET, CT, profilometry, ion mobility spectroscopy, and different forms of microscopy.


Licensing Contact

Karen Rufus

615.322.4295

MemoryMonitor: A real-time neuroscientific learning monitor that knows whether you will later remember something you see

We all wish that we could know if we were going to later remember something, the moment that new information enters our brain. For example, if we could predict whether our children would later remember a vocabulary word, then we could have them spend more time on the words they will not remember. A group of neuroscientists at Vanderbilt University has developed a way of measuring and analyzing brain activity that achieves this goal of predicting later memory as we study and view new information. The procedure involves measuring brainwaves from just two electrodes on the head as people view pictures, words, or virtually any kind of information that a person hopes to remember later.


Licensing Contact

Masood Machingal

615.343.3548

Marker Enrichment Modeling (MEM) Software for Automated Cell Population Characterization and Identification in Complex Tissue Microenvironments

Marker enrichment modeling (MEM) provides a crucial missing piece for true machine learning analysis of cell identities and phenotypes in complex tissue microenvironments, including human immune disorders and cancer.


Licensing Contact

Masood Machingal

615.343.3548

Anti-Insulin Transgenic Mice for the Study of B cells in Type I Diabetes

Two mouse models produce anti-insulin antibodies with enhanced insulin binding capacity, and hence model accelerated TID disease progression. A third mouse model features altered VDJ sequence in the immunoglobulin heavy chain (VH281 Tg line) which produces the non-insulin binding  mutant version of the anti-insulin antibody mAB 125, which models reduced disease progression and severity. Hence these mice can be very useful tools in investigating TID disease mechanism as well as potential therapeutics.


Licensing Contact

Jody Hankins

615.322.5907

Inventors

James Thomas
Research Tools
Animal Model

Human sodium channel beta 1 and beta 2 subunits

HEK-293 cell line stably expressing human sodium channel beta 1 and beta 2 subunits. This cell line expresses the two human sodium channel accessory subunits needed for robust expression of sodium channel protein.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Cell Line

Slc5a7 (choline transporter, CHT) BAC Transgenic Mouse

A Bacterial Artificial Chromosome (BAC) containing the mouseSlc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Animal Model

Recombinant Human Sodium Channel Nav1.5 with Long-QT Syndrome (LQT3) Mutations

Mammalian expression plasmids encoding mutant human voltage-gated sodium channel (NaV1.5) cDNA for use in heterologous expression studies. The plasmids encode versions of NaV1.5 with specific mutations identified in patients with congenital long-QT syndrome type 3 (LQT3 mutations).


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Nucleic Acid/Plasmid