Researchers have developed a non-invasive method for creating vascular occlusions at specific locations within a vessel using magnetic resonance guided focused ultrasound (MRgFUS). The speed and efficacy of this approach is better than traditional vascular occlusion methods, and the method can be further enhanced through the use of phase shift nano-droplets. The approach is even applicable to large vessels that can be extremely challenging to ablate due to the heat sink effect. Ultimately, the ability to occlude selected vasculature could aid in the treatment of vascular malformations, hemorrhage control, and tumor devascularization.