Animal Model

Displaying 1 - 10 of 17


Anti-Insulin Transgenic Mice for the Study of B cells in Type I Diabetes

Two mouse models produce anti-insulin antibodies with enhanced insulin binding capacity, and hence model accelerated TID disease progression. A third mouse model features altered VDJ sequence in the immunoglobulin heavy chain (VH281 Tg line) which produces the non-insulin binding  mutant version of the anti-insulin antibody mAB 125, which models reduced disease progression and severity. Hence these mice can be very useful tools in investigating TID disease mechanism as well as potential therapeutics.


Licensing Contact

Jody Hankins

615.322.5907

Inventors

James Thomas
Research Tools
Animal Model

Slc5a7 (choline transporter, CHT) BAC Transgenic Mouse

A Bacterial Artificial Chromosome (BAC) containing the mouseSlc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Animal Model

Scn1a Knockout Mouse Genetic Model of Epilepsy

This is a unique genetically modified strain ofmice that models Dravet syndrome, a severe infant-onset epileptic encephalopathy. They are maintained on apure 129S6/SvEvTac genetic background to facilitate genetic studies.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Animal Model

GluN2B Floxed Mice (also called NR2B, glutamate receptor 2B)

Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background


Licensing Contact

Jody Hankins

615.322.5907

Inventors

Eric Delpire
Research Tools
Animal Model
Neuroscience/Neurology

Prostaglandin E Receptor-2 Null Mice

Prostaglandin E receptor-2 (EP2) null mice on a C57BL/6 background.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Animal Model
Cardiovascular

Mice with Inducible Cre-ERt Replacing Cytokeratin 19 Coding Region

This research targets CK19.


Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Guoqiang Gu, Anna Means
Research Tools
Animal Model
Oncology

Floxed Endoplasmic Reticulum Kinase (Perk) mice

This research targets Perk.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Douglas Cavener
Research Tools
Animal Model
Oncology

Pancreas Transcription Factor-1 Alpha-Cre Transgenic Mice

This research targets Ptf1a.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Christopher Wright
Research Tools
Animal Model
Oncology

Pancreas Specific Trangenic Mice Overexpressing Either Transmembrane Heparin-binding EGF-like Growth Factor or Secreted HB-EGF

This research targets HB-EGF.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Anna Means
Research Tools
Animal Model

Insulin 2-Akita Heterozygous Mice (DBA/2J strain)

This research targets Ins2 .


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Animal Model