Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background
This is a unique genetically modified strain ofmice that models Dravet syndrome, a severe infant-onset epileptic encephalopathy. They are maintained on apure 129S6/SvEvTac genetic background to facilitate genetic studies.
A Bacterial Artificial Chromosome (BAC) containing the mouseSlc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance.
