Gastrointestinal

Displaying 1 - 7 of 7


Bedside Disposable Endoscope

Bedside Disposable Endoscope


Licensing Contact

Masood Machingal

615.343.3548
Gastrointestinal

Prevention of Cytokine Induced Apoptosis In Intestinal Epithelial Cells By A Probiotic Bacterium

The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn's disease or ulcerative colitis) in a subject, such as a human patient.


Licensing Contact

Janis Elsner

615.343.2430

Inventors

Brent Polk, Fang Yan
Therapeutics
Protein/Peptide
Gastrointestinal

New Clostridium Difficile Recombinant Toxin for Safe Vaccine Development

A structural biology approach has identified a conserved region common to multiple Clostridium toxins. Specific mutations of the protein sequence in this region prevent the toxins from entering into intestinal cells, thereby preventing widespread tissue damage. These recombinant Clostridium toxins may be used to create a multivalent vaccine to protect against multiple species of Clostridium. Furthermore, the recombinant toxin may be used as a safer alternative to the native toxins in vaccine manufacturing. This discovery stems from a collaboration between the laboratories of Dr. Borden Lacy of Vanderbilt University and Dr. Roman Melnyk of the Hospital for Sick Children.


Licensing Contact

Jody Hankins

615.322.5907

Inexpensive Disposable Hydro-Jet Capsule Robot for Gastric Cancer Screening in Low-Income Countries

Gastric cancer is the second leading cause of cancer death worldwide. While screening programs have had a tremendous impact on reducing mortality, the majority of cases occur in low and middle-income countries (LMIC). Typically, screening for gastric and esophageal cancer is performed using a flexible endoscope; however, endoscopy resources for these settings are traditionally limited. With the development of an inexpensive, disposable system by Vanderbilt researchers, gastroscopy and colonoscopy can be facilitated in areas hampered by a lack of access to the appropriate means.


Licensing Contact

Masood Machingal

615.343.3548

Wireless Tablet Application for Remote Collaboration and Training in Colonoscopy

Colorectal cancer is the fourth leading cause of cancer-related mortality in the world. During patient screenings for populations at risk, polyp detection rates depend on the endoscopist's ability to identify the lesions, which takes years of practice and training. Endoscopic training can be challenging for the trainee and preceptor. Frustration can result from ineffective communication regarding areas of interest. Our team developed a novel tablet application for real-time mirroring of the colonoscopy examination that allows preceptors to make annotations directly on the viewing monitor that facilitates medical training and enables collaboration among several endoscopists during a procedure.


Licensing Contact

Masood Machingal

615.343.3548

Local Magnetic Actuation for Obese And Pediatric Patients

Researchers in Vanderbilt University's STORM Lab have developed a novel actuation system that uses magnetic coupling to transmit mechanical power across a physical barrier. This technology is particularly suited for use in minimally invasive surgical procedures for manipulating surgical instruments across tissue barriers.


Licensing Contact

Masood Machingal

615.343.3548
Robotics
Gastrointestinal

Wireless Tissue Palpation for Minimally Invasive Robotic Surgery Techniques

Researchers in Vanderbilt University's STORM Lab have developed a wireless palpation device that uses magnetic coupling between two units to provide valuable feedback about tissue properties and potential abnormalities. The wireless capabilities of this technology make it ideally suited for minimally invasive surgery and natural orifice procedures, as the device does not require the use of a surgical port.


Licensing Contact

Masood Machingal

615.343.3548
Gastrointestinal