Browse Technologies

Displaying 11 - 20 of 50

COX2 Probes for Multimodal Imaging

Inventors at Vanderbilt University have developed a novel chemical design and synthesis process for azulene-based COX2 contrast agents which can be used for molecular imaging, via a variety of imaging techniques. These COX2 probes can be utilized for numerous applications, including imaging cancers and inflammation caused by arthritis and cardiovascular diseases. The process for developing these COX2 contrast agents has been significantly improved through a convergent synthesis process which reduces the required steps to establish the COX2 precursors.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Wellington Pham, Donald Nolting, John Gore
Category:
Medical Imaging

Heterogeneous catalysis of NMR Signal Amplification by Reversible Exchange(SABRE)

Vanderbilt researchers have developed heterogeneous catalysis and catalyst for the NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization process. Coupled with the researchers' development of a method to perform SABRE in aqueous solutions, this discovery could allow fully biocompatible SABRE hyperpolarization processes in water with catalyst recycling. This would allow the production of pure aqueous contrast agents requiring only parahydrogen as a consumable.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Eduard Chekmenev, Boyd Goodson, Fan Shi, Aaron Coffey
Category:
Medical Imaging

Low-cost, Normally Closed Microfluidic Valve

Vanderbilt researchers have developed a normally closed valve that is able to provide selective movement of small fluid quantities in a microfluidic device. The present microfluidic valve can be actuated using a simple rotating drivehead and mechanical support, greatly simplifying the valve design.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

John Wikswo, Jr., Dmitry Markov, Lisa McCawley, John McLean, David Cliffel, Randy Reiserer, Philip Samson, Frank Block, Jennifer McKenzie, William Matloff, Hunter Tidwell, Joseph Scherrer, Erik Werner
Category:
Diagnostics Microfluidics

Miniature Optical Coherence Tomography Probe for Real-time Monitoring of Surgery

Vanderbilt researchers have designed a forward scanning miniature intraoperative Optical Coherence Tomography (OCT) probe that can be used for diagnostic purposes and real-time monitoring of surgery within small spaces, such as endoscopic surgery, intraocular surgery, and other microsurgery.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Karen Joos, Jin-Hui Shen, M. Hutson, John Kozub
Category:
Medical Devices Medical Imaging

Model-based Compression Correction Framework for Ultrasound

Vanderbilt researchers have developed a system that corrects for compressional effects in ultrasound data during soft tissue imaging. The system uses tracking and digitization information to detect the pose of the ultrasound probe during imaging, and then couples this information with a biomechanical model of the tissue to correct compressional effects during intraoperative imaging.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Michael Miga, Thomas Pheiffer, Dave Smith
Category:
Computer Science & Communications Medical Imaging

NMR Signal Amplification by Reversible Exchange (SABRE) in Water

Vanderbilt researchers have developed a method to perform the Parahydrogen Induced Polarization (PHIP) based method of Signal Amplification by Reversible Exchange (SABRE) in aqueous media. This allows the resulting hyperpolarized molecules to be used for in vivo applications.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Eduard Chekmenev, Boyd Goodson, Milton Truong, Ping He, Quinn Best, Fan Shi, Kirsten Groome, Aaron Coffey, Roman Shchepin
Category:
Medical Imaging

System and Methods of Using Image-guidance for Placement of Cochlear Stimulator Devices, Drug Carrier Devices, or the Like

Vanderbilt inventors have developed and tested a device (C-in) and method that would shift the current invasive, risky surgical procedure of cochlear implantation to a less invasive outpatient procedure.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Robert Labadie, J Michael Fitzpatrick
Category:
Medical Devices Medical Imaging

Two Degrees-of-Freedom, Fluid Power Stepper Actuator Model

Vanderbilt researchers have developed a novel technology for use of a flexible fluidic actuator in MRI-guided surgical systems. This method eliminates the need for moving the patient out of the MRI machine, onto an operating table, and back in order to perform procedures. It is a safe, sterilized, and successful method to simplify MRI-guided surgical procedures.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

David Comber, Eric Barth, Jonathan Slightam, Vito Gervasi
Category:
Medical Devices Medical Imaging

Diagnostics Management Team

The sheer volume of medical information available to physicians today is overwhelming. Diagnostic Management Team provides a concise, accurate method for ordering the correct diagnostic tests every time, and it returns the results in a uniform report format, easily read by the physician. This has already been launched within Vanderbilt University, with a high adoption rate amongst physicians and has already shown significant savings.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Mary Zutter
Category:
Diagnostics Health Care IT
Field of Use:
Oncology

One-Step Hydrosilylation for Click Chemistry Compatible Surfaces

Vanderbilt inventors have developed a one-step hydrosilylation synthesis of azide surfaces for the preparation of click chemistry compatible substrates. In this process, an organic azide is formed in a single step on a hydrogen-terminated silicon support, yielding a surface that is ready to undergo click reactions as desired. Simple, efficient, and versatile, click chemistry is widely used and is particularly useful for biosensing applications. A click reaction can be utilized to attach a molecular or biological probe for point-of-care diagnostics and chemical screening.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Bradley Baker, Paul Laibinis
Category:
Diagnostics Thin Films & Nanomaterials