-
Development of a Commercial Assay for Clonal Hematopoiesis of Indeterminate Potential (CHIP)
This project develops a targeted genomic assay and custom bioinformatic pipeline to detect CHIP variants with high sensitivity and at dramatically reduced cost. The approach captures key genomic regions, enables deep sequencing for low-frequency variant detection, and is positioned for clinical…
-
Exponentially scalable PCR for multiplex detection of pathogens in a single tube
This project develops a general method for highly multiplexed PCR in a single tube, using mediator probes and a combinatoric algorithm to enable exponential scaling of target detection. The approach simplifies assay implementation and instrumentation while reducing reagent use and cost, with…
-
Advanced Prototype Development for an Ultra-low-cost Dermatoscope
Early detection of skin cancer is often delayed because patients and primary care providers lack tools to capture high-quality images for remote review. This project develops a low-cost, paper-based dermatoscope with enhancements and a prototype mobile app, while pursuing patentable features to…
-
-
-
-
-
Pulmonary Fibrosis Treatment With Nebulized Prodrug HIF2-Antagonists
This technology focuses on developing HIF2 inhibitors to enhance adaptive lung repair for targeted pulmonary fibrosis treatment. The follow-on award will advance this system, which leverages endogenous bioactivation.
-
-
Developing an AI Platform to Provide Point-of-Care Educational Decision Support (EDS) to Academic Medical Centers (AMCs):
VLRChat is an AI chatbot that answers clinical questions using retrieval-augmented generation on peer-reviewed medical content. The follow-on award will support the development of xLR, an interoperable multi-institutional platform.