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Advancing LANTERN: From Research Pipeline to Scalable Reading Analytics Platform
LANTERN is an AI-powered assessment platform that evaluates student reading development through oral reading and spoken retell responses. The platform combines speech-to-text transcription with network analysis to measure reading fluency, reading errors, thematic coherence, and comprehension…
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Development of a Bent Stent for Treatment of Trigeminal Neuralgia
This team is developing a minimally invasive endovascular alternative to microvascular decompression for the treatment of trigeminal neuralgia. The approach uses a modified endovascular stent to separate offending blood vessels from the trigeminal nerve root entry zone without requiring open…
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Programmable Blebbisomes as Translation-Competent Biologic Production and Immune-Stealth Delivery Platforms
Blebbisomes are a newly discovered class of large, motile extracellular vesicles being developed as a programmable platform for therapeutic delivery and cell-free protein production. The technology enables exogenous mRNA loading, protein translation after isolation, and engineered surface…
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Pilot Manufacturing and Structured Clinical Validation of the Intrinsic Glove
The Intrinsic Glove is a motion-permissive hand orthosis designed to maintain intrinsic-plus positioning while allowing controlled finger and thumb mobility. The device provides semi-rigid support, compression, and breathable stabilization in a prefabricated yet customizable format that can be…
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Hilary Tindle
Hilary A. Tindle, MD, MPH, is a tenured Professor of Medicine in the Division of General Internal Medicine and Public Health at Vanderbilt University Medical Center. She is the founding director of the Vanderbilt Center for Tobacco Addiction and Lifestyle (ViTAL),…
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Nose-to-Brain (N2B) Delivery of a GLP-1 Receptor Agonist to Treat Addiction
This project develops a novel delivery system for a GLP-1 receptor agonist to treat alcohol and nicotine dependence. The approach leverages advanced technologies to enable optimal targeting of the agent. The project evaluates candidate agents and tests a lead formulation in a preclinical model…