Biochemistry

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Correctly copying DNA - new research from Neil Osheroff

The enzyme topoisomerase II resolves topological roadblocks that form during the copying and expression of genetic material by generating double-stranded breaks in one DNA segment, transporting another DNA segment through the break, and rejoining the two ends.


New algorithm calculates drug synergy; initial tests involve melanoma, lung cancer

Drug combinations used for the treatment of non-small-cell lung cancer (NSCLC) and melanoma aren’t as effective as they could be.