Browse Technologies

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Trimodal Handheld Probe Based on Raman Spectroscopy and Confocal Imaging for Cancer Detection

This technology relates to a device and method for non-invasive evaluation of a target of interest of a living subject, and in particular to devices and methods that integrate confocal imaging with confocal Raman spectroscopy, for non-invasive evaluation of the biochemical compositions and morphological details of normal and cancerous skin lesions of a living subject.


Licensing Contact

Ashok Choudhury

615.322.2503

System for Determining the Orientation of a Bone Implanted Post

A method for determining an orientation of a base to which a fiducial marker is detachably mounted. The method includes the steps of determining the axis of symmetry for the fiducial marker and choosing the determined axis of symmetry of the fiducial marker as the axis of symmetry of the base.


Licensing Contact

Taylor Jordan

615.936.7505
Medical Devices

Optical Stimulation of the Auditory Nerve

A cochlear implant placed in a cochlea of a living subject for stimulating the auditory system of the living subject, where the auditory system comprises auditory neurons. In one embodiment, the cochlear implant includes a plurality of light sources, {L.sub.i}, placeable distal to the cochlea, each light source, L.sub.1, being operable independently and adapted for generating an optical energy, E.sub.i, wherein i=1, . . . , N, and N is the number of the light sources, and delivering means placeable in the cochlea and optically coupled to the plurality of light sources, {L.sub.i}, such that in operation, the optical energies {E.sub.i} generated by the plurality of light sources {L.sub.i} are delivered to target sites, {G.sub.i}, of auditory neurons, respectively, wherein the target sites G.sub.1 and G.sub.N of auditory neurons are substantially proximate to the apical end and the basal end of the cochlea, respectively.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices

Improved Piezoimmunosensor

An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single V.sub.H chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.


Licensing Contact

Mike Villalobos

615.322.6751
Diagnostics

Method for the Automatic Segmentation of the Facial Nerve and the Chorda Tympani in CT Images

This is a high resolution imaging device that can detect the fundamental functional units of cortical organization. Currently, with existing technology, we are able to monitor the activity of these units in the awake, head-fixed animal using large standard sized cameras mounted on heavy camera arms. However, we need a capability to conduct such monitoring in the awake and freely moving animal so that we can relate specific patterns of cortical activity to natural behaviors.


Licensing Contact

Taylor Jordan

615.936.7505
Medical Imaging

System for Determining the Orientation of a Bone-Implanted Anchor

A method for simplifying the process of designing a platform for minimally invasive surgery. The platform is designed to attach to a set of bone-implanted anchors attached to the patient. This method makes the fitting of the platform to the anchors simpler and easier.


Licensing Contact

Taylor Jordan

615.936.7505
Medical Devices