Basic Sciences

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Evading cell death

Cancer cells can develop resistance to the treatments designed to eliminate them. Several studies have linked stress granules (SGs), cell organelles that form transiently in response to extracellular stress, to this phenomenon. However, how SGs protect cancer cells remains unclear.

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Research Basic Sciences cancer drug resistance susen wente Department of Cell and Developmental Biology. laura glass

Targeting diabetic kidney disease

Targeting diabetic kidney disease

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Research Basic Sciences diabetes diabetic nephropathy EGF EGFR Raymond Harris division of nephrology

Cellular stress defense

Cellular stress defense

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Research Basic Sciences cellular stress response Hassane Mchaourab biology

Insulin accelerant

The condition known as insulin resistance

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Research Basic Sciences David Wasserman diabetes insulin insulin resistance nitric oxide

Mass spectrometry team earns grant to map body at the cellular level

A team of Vanderbilt University imaging experts won grants in the first round of the National Institutes of Health’s Human BioMolecular Atlas Program (HuBMAP) funding, aimed at developing an open, global framework to map the adult human body at the level of individual cells.

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Health and Medicine Research Basic Sciences Danielle Gutierrez department of biochemistry Jeff Scraggins Ken Lau Mark deCaestecker Mass Spectrometry Research Center Raf Van de Plas Raymond Harris Richard Caprioli School of Medicine

Unleashing TIGER on small RNAs

Efforts to explore the landscape of small RNAs (sRNAs) — short RNA molecules that are poorly understood — often use high-throughput sequencing (sRNA-seq). These efforts are hampered by a lack of tools to identify, quantify and analyze all the different sRNAs in sRNA-seq datasets.

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American Heart Association Basic Sciences Department of Medicine Journal of Extracellular Vesicles Kasey Vickers Molecular Physiology & Biophysics NCATS NCI NHLBI NIDDK NIGMS NIH RNA

Predictive models for gene regulation

Predictive models for gene regulation

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Research Basic Sciences big data gene expression gene regulation Gregor Neuert molecular physiology and biophysics Proceedings of the National Academy of Sciences

Scavengers “protect” HDL

High-density lipoprotein (HDL) is widely thought to protect against the development of atherosclerosis, yet drugs that raise levels of HDL cholesterol (HDL-C) have failed to reduce the risk of heart disease.

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AHA American Heart Association atherosclerosis Basic Sciences cholesterol Department of Pharmacology HDL Journal of Biological Chemistry NHLBI NIH Research Sean Davies

Roden’s circulatory diseases research honored

Vanderbilt University’s Dan Roden, MD, internationally known for his contributions to understanding how genetic variation affects drug response, has been named a recipient of the 2018 Louis and Artur Lucian Award for Research in Circulatory Diseases by McGill University in Montreal, Canada.

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Dan Roden Award for Research in Circulatory Diseases Basic Sciences cardiovascular disease Department of Biomedical Informatics Department of Medicine Department of Pharmacology John A. Oates Institute for Experimental Therapeutics McGill University personalized medicine

$8.1 million grant funds new center to research highly aggressive form of lung cancer

Vanderbilt University has been awarded a five-year, $8.1-million grant from the National Cancer Institute to serve as a research center in the institute’s prestigious Cancer Systems Biology Consortium.

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Health and Medicine Basic Sciences Biochemistry cancer cell and developmental biology Lawrence J. Marnett National Cancer Institute NCI Cancer Systems Biology Consortium Pharmacology School of Medicine Vito Quaranta