Imaging

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Metabolic Labeling Reagents for Chondroitin Sulfate

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans. These stunning images demonstrate incorporation of these metabolic labeling reagents to track neurodevelopmental processes in a zebrafish model system. Notably, the metabolic label can be detected post vivo using a standard ""click"" chemistry reaction. Further, Dr. Page-McCaw has optimized a background reduction strategy to complement this technology by improving the signal-to-noise ratio.


Licensing Contact

Mike Villalobos

615.322.6751
Research Tools
Imaging
Research Reagent

Near-Infrared Dye with Large Stokes Shift for Simultaneous Multichannel in vivo Molecular Imaging

Fluorescent labels having near-infrared (NIR) emission wavelengths have the ability to penetrate tissue deeper than other emission wavelengths, providing enormous potential for non-invasive imaging applications. However, advancement of optical imaging (particularly NIR imaging) is hindered by the limitation of narrow Stokes shift of most infrared dyes currently available in the market. Vanderbilt researchers have developed a novel NIR dye (4-Sulfonir) for multichannel imaging that enables in vivo imaging of multiple targets due to its large Stokes shift. 4-Sulfonir with its unique large Stokes shift (~150 nm) and wide excitation spectrum could be used in parallel with other NIR dyes for imaging two molecular events simultaneously in one target.


Licensing Contact

Masood Machingal

615.343.3548