Blog

Quick DNA test for malaria drug resistance is life-saver, holds promise for other diseases

Mindy Leelawong, research assistant professor of biomedical engineering, said the problem of drug-resistant malaria is prevalent in Southeast Asia and may spread to Africa and beyond. Doctors currently can tell whether powerful malaria drugs will work on someone or not through polymerase chain reaction (PCR), or a DNA duplication method that allows for optical detection of a disease’s biomarkers with only a sample. However, they formerly had to extract the malaria parasite’s DNA first, virtually impossible to do in rural, low-resource areas.


Steroid binding to metabolic enzyme

The human cytochrome P450 enzymes are responsible for metabolizing a variety of substances — from lipids (fats) and steroid hormones to drugs and toxic chemicals.

One such enzyme, P450 17A1, generates androstenedione and dehydroepiandrosterone (DHEA), involved in the production of sex hormones. How the enzyme binds to its substrates has remained a mystery until now.


New leadership announced for the Wond’ry

David A. Owens has been named the Evans Family Executive Director of the Wond’ry.