Fred guengerich

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Steroid binding to metabolic enzyme

The human cytochrome P450 enzymes are responsible for metabolizing a variety of substances — from lipids (fats) and steroid hormones to drugs and toxic chemicals.

One such enzyme, P450 17A1, generates androstenedione and dehydroepiandrosterone (DHEA), involved in the production of sex hormones. How the enzyme binds to its substrates has remained a mystery until now.