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Rabbit Anti-human Large Neutral Amino Acid Transporter Antibody

This research targets LAT-1.


Licensing Contact

Karen Rufus
karen.rufus@vanderbilt.edu
615.322.4295

Inventors

Roy Zent
Research Tools
Antibody

HEK-293 Cell Line Overexpressing Neuronal Potassium Chloride Cotransporter

KCC2 is a neuronal-specific K-CI cotransporter which plays a major role in maintaining intracellular Cl- concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses.


Licensing Contact

Jody Hankins
jody.hankins@vanderbilt.edu
615.322.5907
Research Tools
Cell Line
Neuroscience/Neurology

HEK Cells with Stable Expression of Human Brain Sodium Channel Nav1.1 Subunits (SCN1A, SCN1B, and SCN2B)

This is a human embryonic kidney cell line that stably expresses the three component proteins of the brain Navl.l voltage-gated sodium channel (SCNlA, SCNlB and SCN2B). The invention is important because mutation of the gene SCNlA is the most common cause of inherited epilepsy syndromes. In addition, voltage- gated sodium channels are important drug targets for anticonvulsant therapies. To our knowledge, this is the first cell line to simultaneously express all three components of Navl.l. The expression of all three proteins has been confirmed using western blot analysis. The stable cell line expresses the appropriate Nav


Licensing Contact

Karen Rufus
karen.rufus@vanderbilt.edu
615.322.4295
Research Tools
Cell Line
Neuroscience/Neurology