Neuroscience/Neurology

Displaying 1 - 7 of 7


mGlu3 NAMs as Therapeutics for Chemoresistant Tumors

Targeting metabotropic glutamate receptor 3 (mGlu3) has been linked as a potential therapeutic to many neurological disorders and well as oncology through the use of dual specific mGlu2/3 Antagonists (LY341495, RO4491533, MGS0039, RO4988546).


Licensing Contact

Mike Villalobos

615.322.6751
Therapeutics
Small Molecule

Small Molecule mGlu3 NAMs as Therapeutics for CNS Disorders

The Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) has a mission to promote the translation of advances in basic science towards novel therapeutics. They have recruited faculty and staff with experience at over 10 different pharmaceutical companies to ensure a diverse set of approaches, techniques and philosophies to advancing compounds. Together they aim to de-risk drug discovery programs.


Licensing Contact

Mike Villalobos

615.322.6751
Therapeutics
Small Molecule

An Ergothioneine PET Radioligand for Imaging Oxidative Stress in Alzheimer's Disease

Vanderbilt researchers lead by Professor Wellington Pham, PhD, have developed a novel ergothioneine (ERGO) PET radioligand for imaging oxidative stress in Alzheimer's disease.


Licensing Contact

Masood Machingal

615.343.3548
Therapeutics
Neuroscience/Neurology

Endonasal Surgical Robot for Sinus and Neurosurgery

Vanderbilt engineers have developed a robotic system for performing sinus and neurosurgery through the nose. This provides a less invasive way to access surgical sites in the sinuses and near the middle of the patient's head, leading to faster recovery times. The robot is modular and sterilizable with detachable cartridge-based instruments. Each instrument is a concentric tube robot, which is a needle-sized tool that can bend and elongate. The system delivers four of these instruments through a single nostril.


Licensing Contact

Ashok Choudhury

615.322.2503

GluN2B Floxed Mice (also called NR2B, glutamate receptor 2B)

Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background


Licensing Contact

Cameron Sargent

615.343.2430

Inventors

Eric Delpire
Research Tools
Neuroscience/Neurology
Animal Model

HEK293 Cell Line with Stable Expression of Drosophila Serotonin Re-Uptake Transporter

This research targets SERT.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Neuroscience/Neurology
Cell Line

Mouse Model for Cardiovascular/Autonomic Disorders

This research targets CHT.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Animal Model