Cancer Research

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Discovery aids search for cancer biomarkers

A report by researchers at Vanderbilt University Medical Center has shattered conventional wisdom about how cells, including cancer cells, shed DNA into the bloodstream: they don’t do it by packaging the genetic material in tiny vesicles called exosomes.

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Cancer Research Cell Dennis Jeppesen exome NIH Research Robert Coffey

Discovery points to new cancer immunotherapy option

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer.

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Amy and Barry Baker Lab cancer immunotherapy Cancer Research checkpoint inhibitors department of otolaryngology Flow Cytometry Shared Resource immune system immunotherapy t cell Vanderbilt Ingram Cancer Center Vanderbilt Institute for Infection Immunology and Inflammation Young Kim

Breast cancer-killing RIG

Immune checkpoint inhibitors — cancer therapies that remove the “brakes” on the adaptive anti-tumor immune response — have had remarkable success in melanoma and lung cancer.

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Health and Medicine Research antivirus Basic Sciences breast cancer cancer cancer biology immunotherapy Cancer Research checkpoint inhibitors Department of Cell and Developmental Biology immune response national science foundation Rebecca Cook Vanderbilt Ingram Cancer Center