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Treating Glioblastoma by a Combination Therapy of Gamma-secretase inhibitors and Farnesyltransferase Inhibitors

Scientists at Vanderbilt have developed a novel therapy for gliobastoma multiform that results in minimal recurrence of the tumor. The therapy combines two inhibitors that effectively compromise tumor cell growth and survival. The therapy can be followed by radiation, a common treatment for cancer cells.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Jialiang Wang
Therapeutics

Inhibitors of Inward-Rectifying Potassium Channels (Insecticide)

This research targets IRK.


Licensing Contact

Tom Utley

615.343.3852

Assay for Novel Serotonin Transporter Blockers

The mutant SERTs we have developed can provide for a platform to screen for novel modes/molecules interrupting SERT function. As SERT blockers are effective antidepressants, this strategy can lead to novel antidepressant medications. It may also be useful in development of animal models to test antidepressant action in vivo.


Licensing Contact

Karen Rufus

615.322.4295

Use of mGluR5 Partial Antagonists for the Treatment of Anxiety and Other CNS Disorders

Provided is a method of treating conditions and disorders for which full mGluR5 antagonists are potentially effective, such as, e.g., anxiety, epilepsy, schizophrenia and other psychotic disorders, Parkinson's disease, addictive disorders, and the like in a subject in need of such treatment, comprising administration to such subject of a therapeutically effective amount of a partial, non-competitive mGluR5 antagonist compound of the invention.


Licensing Contact

Tom Utley

615.343.3852

Micro and NanoParticulate Polymeric Delivery System

The present invention provides a method of making particles useful in drug delivery, comprising the steps of: contacting polyanionic polymers with cations in a stirred reactor so that polyanions and the cations react to form particles.


Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Ales Prokop
Therapeutics