Browse Technologies

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'Coffee Ring' Diagnostic for Point-of-Care Biomarker Detection

Bright minds at Vanderbilt University have unveiled a breakthrough technology that could bring sophisticated biomarker diagnostics to the developing world. The point-of-care diagnostic is designed to be used in the field; no specialized equipment, expertise, or white lab coats are required. The diagnostic is based upon the ingenous observation that evaporating liquid droplets leave behind a characteristic ring pattern, which may be familiar to our readers in the form of a coffee-ring stain.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Frederick Haselton, David Wright, Josh Trantum
Category:
Diagnostics

Porous Silicon Membrane Waveguide Biosensor

Vanderbilt researchers have developed a low-cost, high sensitivity sensor based on a porous silicon (PSi) membrane waveguide. This sensor is designed to be a cost-effective alternative to conventional fiber optic and SPR sensors for both biosensing and chemical sensing applications.

Licensing Contact

Yiorgos Kostoulas

615.322.9790

Inventors

Guoguang Rong, Raymond Mernaugh, Sharon Weiss
Category:
Diagnostics Thin Films & Nanomaterials

Trimodal Handheld Probe Based on Raman Spectroscopy and Confocal Imaging for Cancer Detection

This technology relates to a device and method for non-invasive evaluation of a target of interest of a living subject, and in particular to devices and methods that integrate confocal imaging with confocal Raman spectroscopy, for non-invasive evaluation of the biochemical compositions and morphological details of normal and cancerous skin lesions of a living subject.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Anita Mahadevan-Jansen, David Dickensheets, Chad Lieber
Category:
Diagnostics Medical Devices Medical Imaging

Improved Piezoimmunosensor

An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single V.sub.H chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.

Licensing Contact

Mike Villalobos

615.322.6751

Inventors

Raymond Mernaugh, Xiangqun Zeng, Gabrielle Stryker
Category:
Diagnostics