Browse Technologies

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Olfactory Genes from the Malaria Mosquito

This technology facilitates the discovery and design of novel agents for either repelling or otherwise controlling insects that have important economic or medical significance. In particular, mosquitoes are responsible for transmitting a number of diseases, including malaria, West Nile, dengue and yellow fevers. The Zwiebel laboratory has identified human odorants and the protein receptors in mosquitoes that allow female mosquitoes to identify their hosts when they need blood to satisfy their reproductive needs. With funding from the Gates Foundation's Grand Challenge in Global Health initiative, the Zwiebel laboratory, along with collaborators at Yale, Wageningen University in the Netherlands, and researchers in Africa, developed biological and behavioral assays to screen and test numerous agents as potential repellants and attractants for the Anopholes gambiae mosquito.
These methods have been applied to include agricultural pests, disease vectors and nuisance insects (important for many tourist-based economies).


Licensing Contact

Janis Elsner

615.343.2430

Inventors

Laurence Zwiebel
Research Tools

Lipoxygenase Proteins and Nucleic Acids

Isolated and purified lipoxygenase proteins and nucleic acids are described. Particularly, a novel human 15(S) lipoxygenase (15-Lox-2) protein and cDNA and a cDNA for mouse 8S-lipoxygenase are described. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also described, along with methods of producing each. Isolated and purified antibodies to 15-Lox-2 and 8-Lox, and methods of producing the same, are also described.


Licensing Contact

Janis Elsner

615.343.2430

Inventors

Alan Brash

Integrated Device for Leaching Extraction and Assessment

The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents with low aqueous solubility.


Licensing Contact

Chris Harris

615.343.4433
Research Tools

Heterologous Expression System for Studying Recombinant Human Brain Voltage-Gated Sodium Channel, SCN1A

Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Nucleic Acid/Plasmid

EP4 Transgenic Mice

EP4 Transgenic Mice are part of the Vanderbilt Research Tools Catalog.


Licensing Contact

Karen Rufus

615.322.4295

Cell Line with Stable Expression of Human Skeletal Muscle Sodium Channel (hSkM1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle voltage-gated sodium channel (hSkMl). The cells enable high throughput screening of compounds that modulate sodium channel activity.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Cell Line

Cell Line with Stable Expression of Human Cardiac Sodium Channel (hH1, a.k.a. hNav1.5, SCN5A)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George, Dao Wang
Research Tools
Cell Line
Cardiovascular

Cell Line with Stable Expression of Recombinant Human Chloride Channel, hCIC-4

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human chloride channel (hClC-4). The cells enable high throughput screening of compounds that modulate chloride channel activity.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Cell Line

Cell Line with Stable Expression of Recombinant Human Skeletal Muscle Chloride Channel (hCIC-1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle chloride channel (hClC-1). The cells enable high throughput screening of compounds that modulate chloride channel activity.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Cell Line
Neuroscience/Neurology

HEK-293 Cell Line Containing the Human Norepiephrine Transporter cDNA (Norepi Cell Line)


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Cell Line
Cardiovascular