Browse Technologies

Displaying 61 - 70 of 70

Lipoxygenase Proteins and Nucleic Acids

Isolated and purified lipoxygenase proteins and nucleic acids are described. Particularly, a novel human 15(S) lipoxygenase (15-Lox-2) protein and cDNA and a cDNA for mouse 8S-lipoxygenase are described. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also described, along with methods of producing each. Isolated and purified antibodies to 15-Lox-2 and 8-Lox, and methods of producing the same, are also described.

Licensing Contact

Janis Elsner

615.343.2430

Inventors

Alan Brash
Category:
Research Tools
Product Type:
Nucleic Acid/Plasmid
Field of Use:
Cardiovascular Inflammatory/Immune

Integrated Device for Leaching Extraction and Assessment

The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents with low aqueous solubility.

Licensing Contact

Chris Harris

615.343.4433

Inventors

David Kosson, Leslie Shor, Andrew Garrabrants
Category:
Research Tools

Heterologous Expression System for Studying Recombinant Human Brain Voltage-Gated Sodium Channel, SCN1A

Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George, Christoph Lossin
Category:
Research Tools
Product Type:
Nucleic Acid/Plasmid

EP4 Transgenic Mice

EP4 Transgenic Mice are part of the Vanderbilt Research Tools Catalog.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Matthew Breyer, Youfei Guan, Andre Schneider
Category:
Research Tools
Product Type:
Animal Model
Field of Use:
Cardiovascular Inflammatory/Immune Oncology

Cell Line with Stable Expression of Human Skeletal Muscle Sodium Channel (hSkM1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle voltage-gated sodium channel (hSkMl). The cells enable high throughput screening of compounds that modulate sodium channel activity.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Category:
Research Tools
Product Type:
Cell Line
Field of Use:
Cardiovascular Neuroscience/Neurology

Cell Line with Stable Expression of Human Cardiac Sodium Channel (hH1, a.k.a. hNav1.5, SCN5A)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George, Dao Wang
Category:
Research Tools
Product Type:
Cell Line
Field of Use:
Cardiovascular

Cell Line with Stable Expression of Recombinant Human Chloride Channel, hCIC-4

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human chloride channel (hClC-4). The cells enable high throughput screening of compounds that modulate chloride channel activity.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George, Christoph Fahlke
Category:
Research Tools
Product Type:
Cell Line
Field of Use:
Cardiovascular Neuroscience/Neurology

Cell Line with Stable Expression of Recombinant Human Skeletal Muscle Chloride Channel (hCIC-1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle chloride channel (hClC-1). The cells enable high throughput screening of compounds that modulate chloride channel activity.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Category:
Research Tools
Product Type:
Cell Line
Field of Use:
Neuroscience/Neurology

HEK-293 Cell Line Containing the Human Norepiephrine Transporter cDNA (Norepi Cell Line)

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Category:
Research Tools
Product Type:
Cell Line
Field of Use:
Cardiovascular

MMP-7 Null Mice

The only MMP-7-null mouse that has been generated. Used to determine biological function of MMP-7. Mice have been used in more than 10 publications at this point, and will be distributed by a commercial vendor in the near future.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Lynn Matrisian, Carole Wilson
Category:
Research Tools
Product Type:
Animal Model
Field of Use:
Cardiovascular Inflammatory/Immune Oncology