Browse Technologies

Displaying 51 - 60 of 71


Anti-p19 ARF Antibody

This research targets ARG(p19).


Licensing Contact

Mike Villalobos

615.322.6751

Inventors

Stephen Hann
Research Tools
Antibody
Oncology

Anti-human Myeloid Cell Nuclear Differentiation Monoclonal Antibody

The antibody is a rat IgG1 monoclonal, clone 3C1.


Licensing Contact

Jody Hankins

615.322.5907
Research Tools
Antibody
Inflammatory/Immune

Anti-Armadillo Repeat Gene Deleted in Velo-cardiofacial Syndrome Monoclonal Antibody

This research targets ARVCF.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Albert Reynolds
Research Tools
Antibody

GluN2B Floxed Mice (also called NR2B, glutamate receptor 2B)

Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background


Licensing Contact

Jody Hankins

615.322.5907

Inventors

Eric Delpire
Research Tools
Animal Model
Neuroscience/Neurology

Stable HERG Expressing Cells

Vanderbilt researchers have designed a cell line with stable expression of the human heart potassium channel, HERG. This cell line has robust and very consistent cell-to-cell HERG activity without detectable endogenous ionic currents, making it ideal to use in preclinical drug screening.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Cell Line
Cardiovascular

Plasmid Based Reverse Genetics for Reovirus

Scientists at Vanderbilt have developed an entirely plasmid-based system to better utilize reoviruses as a research tool. The system allows for generating a reovirus entirely from cloned cDNAs comprising three steps involving fairly well-known techniques.


Licensing Contact

Mike Villalobos

615.322.6751

Optical Assay of Protein Interactions

This invention provides bioluminescence resonance energy transfer (BRET) system that comprises four parts: 1) a bioluminescent protein that has luciferase activity; 2) an acceptor fluorophore that can accept the energy from the bioluminescent protein when they are associated, in the presence of the appropriate substrate; 3) a modulator that influences the proximity or the orientation of the bioluminescent protein and the fluorophore, and 4) an appropriate substrate to activate the luciferase activity of the bioluminescent protein. The components of this system interact to influence the spatial relationship between the bioluminescent protein and the fluorophore, that is demonstrated by the light emission from the system. The modulator can be a single entity, covalently attached to both the bioluminescent protein and the fluorophore, it can be two separate entities, each linked covalently to either the bioluminescent protein or the fluorophore, or an alternative configuration that falls within the scope of the invention. Thissystem can be used in both in vivo or in vitro assays to detect molecular changes in a wide variety of applications, and is amenable to automation. In particular, it is useful for assaying protein interactions, enzyme activities and the concentration of analytes or signaling molecules in cells or in solution.


Licensing Contact

Mike Villalobos

615.322.6751
Research Tools

Stably-Transfected (HEK-293 cells) Human Serotonin Transporter (hSERT) Cell Line

HEK-293 cells stably-Transfected with Human Serotonin Transporter (hSERT)


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Cell Line

Assay for Novel Serotonin Transporter Blockers

The mutant SERTs we have developed can provide for a platform to screen for novel modes/molecules interrupting SERT function. As SERT blockers are effective antidepressants, this strategy can lead to novel antidepressant medications. It may also be useful in development of animal models to test antidepressant action in vivo.


Licensing Contact

Karen Rufus

615.322.4295

A Method for Genetically Engineering Proteins with Cell Membrane Translocating Activity

The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.


Licensing Contact

Janis Elsner

615.343.2430
Research Tools