Browse Technologies

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Anti-human Myeloid Cell Nuclear Differentiation Monoclonal Antibody

The antibody is a rat IgG1 monoclonal, clone 3C1.


Licensing Contact

Jody Hankins

615.322.5907
Research Tools
Antibody
Inflammatory/Immune

Anti-Armadillo Repeat Gene Deleted in Velo-cardiofacial Syndrome Monoclonal Antibody

This research targets ARVCF.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Albert Reynolds
Research Tools
Antibody

GluN2B Floxed Mice (also called NR2B, glutamate receptor 2B)

Allows for targeted deletion of the GluN2B subunit of NMDA receptors in specific cells or at specific times during development, juvenile, or adult stages. C57BL6/J background


Licensing Contact

Jody Hankins

615.322.5907

Inventors

Eric Delpire
Research Tools
Animal Model
Neuroscience/Neurology

Stable HERG Expressing Cells

Vanderbilt researchers have designed a cell line with stable expression of the human heart potassium channel, HERG. This cell line has robust and very consistent cell-to-cell HERG activity without detectable endogenous ionic currents, making it ideal to use in preclinical drug screening.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Cell Line
Cardiovascular

Stably-Transfected (HEK-293 cells) Human Serotonin Transporter (hSERT) Cell Line

HEK-293 cells stably-Transfected with Human Serotonin Transporter (hSERT)


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Cell Line

Assay for Novel Serotonin Transporter Blockers

The mutant SERTs we have developed can provide for a platform to screen for novel modes/molecules interrupting SERT function. As SERT blockers are effective antidepressants, this strategy can lead to novel antidepressant medications. It may also be useful in development of animal models to test antidepressant action in vivo.


Licensing Contact

Karen Rufus

615.322.4295

A Method for Genetically Engineering Proteins with Cell Membrane Translocating Activity

The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.


Licensing Contact

Janis Elsner

615.343.2430
Research Tools

Lipoxygenase Proteins and Nucleic Acids

Isolated and purified lipoxygenase proteins and nucleic acids are described. Particularly, a novel human 15(S) lipoxygenase (15-Lox-2) protein and cDNA and a cDNA for mouse 8S-lipoxygenase are described. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also described, along with methods of producing each. Isolated and purified antibodies to 15-Lox-2 and 8-Lox, and methods of producing the same, are also described.


Licensing Contact

Janis Elsner

615.343.2430

Inventors

Alan Brash

Integrated Device for Leaching Extraction and Assessment

The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents with low aqueous solubility.


Licensing Contact

Chris Harris

615.343.4433
Research Tools

Heterologous Expression System for Studying Recombinant Human Brain Voltage-Gated Sodium Channel, SCN1A

Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Nucleic Acid/Plasmid