Browse Technologies

Displaying 11 - 20 of 70


Mouse Anti-Rabbit Rab25 Monoclonal Antibody

This research targets Rab25.


Licensing Contact

Jody Hankins

615.322.5907

Inventors

James Goldenring
Research Tools
Antibody
Oncology

Cleavable Surfactants for the Analysis of Proteins and Other Biological and Chemical Samples


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Mass Spectrometry Tools

Screening Assay for Molecules That Alter Cell Cycle Rhythm

This research targets Cell Cycle.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Assays/Screening
Oncology Research Reagent

Mice with Inducible Cre-ERt Replacing Cytokeratin 19 Coding Region

This research targets CK19.


Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Guoqiang Gu, Anna Means
Research Tools
Animal Model
Oncology

Human sodium channel beta 1 and beta 2 subunits

HEK-293 cell line stably expressing human sodium channel beta 1 and beta 2 subunits. This cell line expresses the two human sodium channel accessory subunits needed for robust expression of sodium channel protein.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Cell Line

Slc5a7 (choline transporter, CHT) BAC Transgenic Mouse

A Bacterial Artificial Chromosome (BAC) containing the mouseSlc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Animal Model

Recombinant Human Sodium Channel Nav1.5 with Long-QT Syndrome (LQT3) Mutations

Mammalian expression plasmids encoding mutant human voltage-gated sodium channel (NaV1.5) cDNA for use in heterologous expression studies. The plasmids encode versions of NaV1.5 with specific mutations identified in patients with congenital long-QT syndrome type 3 (LQT3 mutations).


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Nucleic Acid/Plasmid

Scn1a Knockout Mouse Genetic Model of Epilepsy

This is a unique genetically modified strain ofmice that models Dravet syndrome, a severe infant-onset epileptic encephalopathy. They are maintained on apure 129S6/SvEvTac genetic background to facilitate genetic studies.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Animal Model

Anti-Insulin Transgenic Mice for the Study of B cells in Type I Diabetes

Two mouse models produce anti-insulin antibodies with enhanced insulin binding capacity, and hence model accelerated TID disease progression. A third mouse model features altered VDJ sequence in the immunoglobulin heavy chain (VH281 Tg line) which produces the non-insulin binding  mutant version of the anti-insulin antibody mAB 125, which models reduced disease progression and severity. Hence these mice can be very useful tools in investigating TID disease mechanism as well as potential therapeutics.


Licensing Contact

Jody Hankins

615.322.5907

Inventors

James Thomas
Research Tools
Animal Model

Metabolic Labeling Reagents for Chondroitin Sulfate

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans. These stunning images demonstrate incorporation of these metabolic labeling reagents to track neurodevelopmental processes in a zebrafish model system. Notably, the metabolic label can be detected post vivo using a standard ""click"" chemistry reaction. Further, Dr. Page-McCaw has optimized a background reduction strategy to complement this technology by improving the signal-to-noise ratio.


Licensing Contact

Mike Villalobos

615.322.6751
Research Tools
Imaging
Research Reagent