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Relaxation Time Discriminated 1H NMR for Bone Mechanical/Fracture Property Diagnostics

Advances in modern MRI pulse sequences, including ultrashort-echo time and related MRI methods for imaging short T2 signals, have enabled clinically-practical cortical bone imaging. Researchers at the Vanderbilt University Institute of Imaging Science have developed a method of distinguishing and quantifying nuclear magnetic resonance (NMR) signals for cortical bone analysis.


Licensing Contact

Chris Harris

615.343.4433

Non-Invasive Cell Size Detection

Vanderbilt researchers have developed a new method for using contrast enhanced MRI to non-invasively map and quantify cell size on a voxel-by-voxel basis. Using this approach, it is possible to monitor and detect diseases or treatments that alter the distribution of cell sizes such as cancer, muscular dystrophy, hepatocellular hypertrophy, and hypertrophic cardiomyopathy.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Real-time Detection of Position and Orientation of Wireless Endoscopy Capsule using Magnetic coupling

Vanderbilt researchers have developed a new system to detect the position, orientation, and pressure exerted on surrounding tissues of a wireless capsule endoscopy device.  Magnetic coupling is one of the few physical phenomena capable of transmitting actuation forces across a physical barrier.  Magnetic manipulation has the potential to make surgery less invasive, by allowing untethered miniature devices to enter the body through natural orifices or tiny incisions, and then maneuver with minimal disruption to healthy tissue.  In order to accomplish this goal, the pose (position and orientation) of the medical device must be available in real time.


Licensing Contact

Masood Machingal

615.343.3548

A Method to Obtain Uniform Radio Frequency Fields in the Body for High Field MRI

Researchers at Vanderbilt have created a new approach to produce uniform radio frequency (RF) fields in the body during high field magnetic resonance imaging (MRI). Existing high field MRI machines create non-uniform RF fields that lead to non-uniform sensitivity in the generated images, also referred to as "hot" and "cold" spots. These local variations interfere with the tissue contrast of the images that radiologists depend upon to make accurate diagnoses. By generating uniform RF fields in the body, this technology provides the benefits of high field MRI without the non-uniform RF fields.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Latent Image-Derived Features for Prognostic Modeling

Researchers at Vanderbilt have developed a system to estimate prognostic metrics such as the length of a hospital stay, recovery status at discharge, and overall health at discharge, using only baseline imaging and clinical information gathered early in the hospital admission process. This system can assist with medical group operations and planning, it can help to educate families and patients regarding prognosis, and can be used to automatically stage patients for clinical trials.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Assessment of Right Ventricular Function Using Contrast Echocardiography

Vanderbilt Medical Center researchers have developed a non-invasive and reproducible method of assessing right-ventricular function using contrast-echocardiography. The right-ventricular transit time (RVTT) measures the time needed for echocardiographic contrast to travel from the RV to the bifurcation of the main pulmonary artery. Coupled with the pulmonary transit time (PTT), the time needed for contrast to traverse the entire pulmonary circulation, RVTT is part of a family of diagnostic parameters that can report on RV-specific performance as well as the RV's function relative to that of the pulmonary circuit as a whole.


Licensing Contact

Chris Harris

615.343.4433

Parahydrogen-Induced Polarizer (PHIP)

The present invention provides a PANACEA (Pneumatics Allow Nonmagnetic Actuation for Creation of Enhanced Alignment) polarizer system. This is an integrated assembly of pneumatically actuated, nonmagnetic hydraulic circuits that enable PASADENA chemicals to be efficiently stored, mixed, and reacted in close proximity or within NMR magnetic fields.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Medical Imaging

Hyper-SHIELDED - Preserving Parahydrogen Spin Order by Efficient Transfer of Nuclear Singlet

Hyperpolarization of nuclear spin ensembles has increased NMR sensitivity to a level that is now enabling detection of metabolism in biological tissue on a time-scale of seconds. The present invention is a pulse sequence that efficiently transforms parahydrogen spin order into heteronuclear magnetization. This was achieved via a single streamlined sequence without recursive application, by finding sequential analytic solutions to the density matrix evolution for each of four independent intervals that collectively flank two proton inversions and one heteronuclear excitation. The name hyper-SHIELDED (Singlet to Heteronuclei by Interative Evolution Locks Dramatic Enhancement for Delivery) reflects the sequence's protective effect on PHIP hyperpolarization.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Simultaneous RNA and Gene Expression Profiling Using Mass Spectrometry

This technology allows the simultaneous detection of RNA transcript abundance (as an assay of gene expression) and protein abundance (as an assay of protein expression) from biological samples without RNA isolation, labeling or amplification. Existing technologies allow for very efficient determinations of protein abundance from a wide variety of biological samples. These methods are in widespread use and are based on mass spectrometry technologies. There are no available technologies that allow efficient and quantitative assessment of multiple RNA transcripts without a previous isolation followed by labeling and/or amplification. The most efficient technologies currently available make use of DNA microarrays to profile RNA abundance as a measure of gene expression. While very robust and useful, these technologies are very labor intensive and suffer from a number of technological drawbacks. This technology takes advantage of a number of existing methods and techniques and brings them together in a novel manner that greatly expands the state of the art for gene expression.


Licensing Contact

Karen Rufus

615.322.4295

Micro-Mirrored Pyramidal Wells

This technology is a system for 3D imaging of live biological cells fabricated using conventional semiconductor technology that provides simultaneous images from multiple vantage points.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Imaging