Browse Technologies

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Non-Invasive Skin Cancer Detection using Raman Spectroscopy-OCT System (Portfolio)

Vanderbilt University researchers have designed a system for non-invasive discrimination between normal and cancerous skin lesions. The system combines the depth-resolving capabilities of OCT technique with Raman Spectroscopy's specificity of molecular chemistry. By linking both imagining techniques into a single detector arm, the complexity, cost, and size of previously reported RS-OCT instruments have been significantly improved. The combined instrument is capable of acquiring data sets that allow for more thorough assessment of a sample than existing optical techniques.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Anita Mahadevan-Jansen, David Dickensheets, Chetan Patil, Tom van Leeuwen, Chad Lieber, Jereon Kalkman
Category:
Diagnostics Medical Devices Medical Imaging

Systems and Methods for Optical Stimulation of Neural Tissues (Portfolio)

Vanderbilt researchers have developed a novel technique for contactless simulation of the central nervous system.  This involves the use of infrared neural stimulation (INS) to evoke the observable action potentials from neurons of the central nervous system.  While infrared neural stimulation of the peripheral nervous system was accomplished almost a decade ago, this is the first technique for infrared stimulation of the central nervous system. This technology has been protected by a portfolio of issued patents.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Eric Jansen, Anita Mahadevan-Jansen, Jonathan Cayce, Austin Duke, Peter Konrad, Jay Walsh, Robert Friedman, Agnelia Izzo, Karthikeyan Mariappan, Jonathon Wells, Claus-Peter Richter, Anna Roe, Changqing Kao, Mykyta Chernov, Charles Lemaire, James Webb, Mark Bendett
Category:
Diagnostics Medical Devices Medical Imaging Therapeutics

Adaptive PCR: A PCR control system to overcome challenging conditions

A PCR control system to overcome challenging conditions. By directly monitoring the hybridization of fluorescently labelled L-DNA mimics of the template DNA strands and primers, it is possible to improve the efficiency of PCR in challenging conditions. This approach eliminates some of the sample preparation and trial and error that would otherwise be required for difficult sample types such as urine or other samples that contain high levels of salts.  In addition, this approach enables on-demand PCR in most any environment.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Frederick Haselton, Elliott Dawson, Nicholas Adams, Steve Simmons
Category:
Diagnostics Medical Devices
Field of Use:
Research Reagent

I-Wire: A Biotension Measurement Device for Tissue Engineering and Pharmacology

Vanderbilt researchers have developed an integrated system ("I-Wire") for the growth of miniature, engineered 3D cardiac or other muscle or connective tissues and their active and passive mechanical characterization. The system utilizes an inverted microscope to measure the strain when the tissue constructs are laterally displaced using a calibrated flexible cantilevered probe.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Philip Samson, Jeffrey Davidson, Stephen Koch, Veniamin Sidorov
Category:
Diagnostics Microfluidics

Low-cost, Normally Closed Microfluidic Valve

Vanderbilt researchers have developed a normally closed valve that is able to provide selective movement of small fluid quantities in a microfluidic device. The present microfluidic valve can be actuated using a simple rotating drivehead and mechanical support, greatly simplifying the valve design.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Dmitry Markov, Lisa McCawley, John McLean, David Cliffel, Ronald Reiserer, Philip Samson, Frank Block, Jennifer McKenzie, William Matloff, William Tidwell, Joseph Scherrer, Erik Werner, DUPE? Frank Block
Category:
Diagnostics Microfluidics

Breast Tumor Margin Detection System Using Spatially Offset Raman Spectroscopy

Vanderbilt University researchers have developed a technology that uses spatially offset Raman spectroscopy to obtain depth-resolved information from the margins of tumors. This helps to determine positive or negative tumor margins in applications such as breast lumpectomy, and the technology is currently being investigated for breast cancer margin detection.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Anita Mahadevan-Jansen, Quyen Nguyen, Matthew Keller, Xiaohong Bi, Mark Kelley, Zain Gowani, Ginger Holt, Isaac Pence, John Nguyen
Category:
Diagnostics Medical Devices Medical Imaging

One-Step Hydrosilylation for Click Chemistry Compatible Surfaces

Vanderbilt inventors have developed a one-step hydrosilylation synthesis of azide surfaces for the preparation of click chemistry compatible substrates. In this process, an organic azide is formed in a single step on a hydrogen-terminated silicon support, yielding a surface that is ready to undergo click reactions as desired. Simple, efficient, and versatile, click chemistry is widely used and is particularly useful for biosensing applications. A click reaction can be utilized to attach a molecular or biological probe for point-of-care diagnostics and chemical screening.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Bradley Baker, Paul Laibinis
Category:
Diagnostics Thin Films & Nanomaterials

Speculum-Free Diagnostic Probe for Optical Assessment of the Cervix

A new approach for obtaining less invasive optical measurements of the cervix has been developed that does not require the use of a speculum exam. This technology can visualize the cervix in vivo to find unique biomarkers that indicate various conditions such as preterm labor, cancer, human papillomavirus (HPV), and dysplasia.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Christine O'Brien, Anita Mahadevan-Jansen, Katherine Cochran, Kristen Findley, William Stokes, Lowell Hays, Mohsin Tejani, Anne-Marie Crowe (nee Crochet)
Category:
Diagnostics Medical Devices Medical Imaging

Non-Invasive Bacterial Identification for Acute Otitis Media using Raman Spectroscopy

Vanderbilt researchers have developed an optical-based method for real-time characterization of middle ear fluid in order to diagnose acute otitis media, also knows as a middle ear infection. The present technique allows for quick detection and identification of bacteria and can also be applied to other biological fluids in vivo.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Anita Mahadevan-Jansen, Oscar Ayala, Eric Skaar, Catherine Wakeman, Jay Werkhaven
Category:
Diagnostics Medical Devices Medical Imaging

A Novel Organs-On-Chip Platform

Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both controlled by the intelligent use of a computer-operated system of pumps and valves. This permits, for the first time, a compact, low-cost system for creating a time-dependent drug dosage profile in a tissue system inside each well.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Frank Block, Dmitry Markov, Philip Samson, David Schaffer, Ronald Reiserer
Category:
Diagnostics Medical Devices Microfluidics Research Tools