Marker enrichment modeling (MEM) provides a crucial missing piece for true machine learning analysis of cell identities and phenotypes in complex tissue microenvironments, including human immune disorders and cancer.
Vanderbilt researchers have developed an in-silico screening method to reveal new indications for existing drugs with known protein targets using a novel infrastructure. The infrastructure integrates multiple factors across system-biology models to create a drug discovery pipeline.
TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models
KnowledgeMap is a web accessible comprehensive content management system with robust mapping capabilities across the entire curriculum (at the level of full lectures, not just outlines or syllabi) that facilitates overall design, management, and evaluation of a coherent and coordinated curriculum.
