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Magnetic resonance imaging (MRI) is one of the most important and versatile tools in the repertoire of diagnostics and medical imaging. Vanderbilt researchers have developed a novel, geometry independent, self-decoupling radiofrequency (RF) coil design that will allow MRI machines to generate images at a faster rate and with greater image quality.

Vanderbilt researchers have identified five key metabolites that, in combination with routine clinical tests, can serve as viable biomarkers for early-stage CKD. This technology offers a robust, minimally invasive, and accurate diagnostic tool that can be deployed in a variety of healthcare settings to improve care and slow or prevent progression to end-stage renal disease.

Vanderbilt researchers have developed a portable, non-invasive sensor system that can take measurements through the skin to provide insights into metabolic rate and energy expenditure outside of a clinical setting. Existing methods for estimating metabolic rate rely on comparisons between user-reported body parameters and population averages, which can result in inaccurate estimates. Additionally, existing portable devices that provide estimates of metabolic rate are limited by factors such as cost per use and frequency of measurement. The present technology overcomes these limitations and can be directly integrated with commercial wearable devices for an accurate assessment of metabolic rate.

Vanderbilt researchers have invented a modular microfluidic bioreactor that can be layered and stacked to create complex organ-on-chip systems that mimic the behavior of human organ systems such as the neurovascular unit. This modular device can also be assembled from separate, functioning biolayers, and at the end of a study disassembled for examination of individual cellular components.