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Small Molecule mGlu3 NAMs as Therapeutics for CNS Disorders

The Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) has a mission to promote the translation of advances in basic science towards novel therapeutics. They have recruited faculty and staff with experience at over 10 different pharmaceutical companies to ensure a diverse set of approaches, techniques and philosophies to advancing compounds. Together they aim to de-risk drug discovery programs.

Licensing Contact

Tom Utley

615.343.3852

Inventors

Craig Lindsley, P. Jeffrey Conn, Kyle Emmitte, Julie Engers, Leah Konkol
Category:
Therapeutics
Field of Use:
Neuroscience/Neurology Oncology

mGlu3 NAMs as Therapeutics for Chemoresistant Tumors

Targeting metabotropic glutamate receptor 3 (mGlu3) has been linked as a potential therapeutic to many neurological disorders and well as oncology through the use of dual specific mGlu2/3 Antagonists (LY341495, RO4491533, MGS0039, RO4988546).

Licensing Contact

Tom Utley

615.343.3852

Inventors

Craig Lindsley, P. Jeffrey Conn, Kyle Emmitte, Julie Engers, Leah Konkol
Category:
Therapeutics
Field of Use:
Neuroscience/Neurology Oncology

TagDock: An Efficient Rigid Body Molecular Docking Algorithm For Three Dimensional Models of Oligomeric Biomolecular Complexes With Limited Experimental Restraint Data

TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Terry Lybrand, Jarrod Smith, Christopher Moth, Sarah Edwards
Category:
Bioinformatics Computer Science & Communications Research Tools

Speculum-Free Diagnostic Probe for Optical Assessment of the Cervix

A new approach for obtaining less invasive optical measurements of the cervix has been developed that does not require the use of a speculum exam. This technology can visualize the cervix in vivo to find unique biomarkers that indicate various conditions such as preterm labor, cancer, human papillomavirus (HPV), and dysplasia.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Christine O'Brien, Anita Mahadevan-Jansen, Katherine Cochran, Kristen Findley, William Stokes, Lowell Hays, Mohsin Tejani, Anne-Marie Crowe (nee Crochet)
Category:
Diagnostics Medical Devices Medical Imaging

Cooling-Triggered Self-Destructing Electronics

Vanderbilt University researchers have developed self-destructing electrical conductors that dissolve and vanish below a certain critical temperature, which is achieved either by actively cooling the circuit or by removing a heat source.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Leon Bellan, Xin Zhang
Category:
General Engineering

Rotary Planar Peristaltic Micropump (RPPM) and Rotary Planar Valve (RPV) for Microfluidic Systems

A Vanderbilt University research team led by Professor John Wikswo has developed low-cost, small-volume, metering peristaltic micropumps and microvalves. These pumps and valves can be used either as stand-alone devices incorporated into microfluidic subsystems, or as readily customized components for research or miniaturized point-of-care instruments, Lab-on-a-Chip devices, and disposable fluid delivery cartridges.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

John Wikswo, Jr., Parker Gould, Loi Hoang, William Matloff, Kevin Seale, Joseph Scherrer, Erica Curtis Anstett, Douglas Hall, Ayeeshik Kole, Ronald Reiserer, William Tidwell, Philip Samson, David Schaffer, Dmitry Markov
Category:
Medical Devices Microfluidics

Continuum Robots with Sensing Capabilities to Adapt Structure

Vanderbilt researchers have developed a continuum robot with the ability to adapt both its length and diameter of its segments. This could help expand the usability and effectiveness of continuum robots.

Licensing Contact

Masood Machingal

615.343.3548
Category:
Robotics

Easily Maneuverable Robotic Control System for a Magnetically Actuated Flexible Endoscope

Vanderbilt researchers have developed a system that allows for active control of the motion of a magnetically actuated flexible endoscope. The system decreases pain during endoscopic procedures and increases clinician control over the endoscope.

Licensing Contact

Masood Machingal

615.343.3548
Category:
Medical Devices

Self-Decoupled RF Coils for Optimized Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is one of the most important and versatile tools in the repertoire of diagnostics and medical imaging. Vanderbilt researchers have developed a novel, geometry independent, self-decoupling radiofrequency (RF) coil design that will allow MRI machines to generate images at a faster rate and with greater image quality.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Xinqiang Yan, John Gore, William Grissom
Category:
Medical Devices Medical Imaging

Low-Cost Non-Invasive Handheld Ultrasound Device for Measuring Tissue Stiffness

Vanderbilt University researchers have developed a hand-held device to quantitatively measure tissue stiffness for medical monitoring. This device is non-invasive, low-cost, and can be used at the point of care.

Licensing Contact

Masood Machingal

615.343.3548
Category:
Diagnostics Medical Devices Medical Imaging