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TagDock: An Efficient Rigid Body Molecular Docking Algorithm For Three Dimensional Models of Oligomeric Biomolecular Complexes With Limited Experimental Restraint Data

TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Terry Lybrand, Jarrod Smith, Christopher Moth, Sarah Edwards
Category:
Bioinformatics Computer Science & Communications Research Tools

Ultrasonic Sensor for Non-intrusive Local Temperature, Transient Temperature and Heat Flux Measurements

An apparatus for measuring the temperature and heat flux of materials through the use of an ultrasonic sensor has been developed at Vanderbilt University. The sensor uses acoustic measurement techniques to determine the heat flux and temperature of material surfaces otherwise inaccessible in particular during system operation in order to enhance monitoring capabilities and reduce unsafe or impaired function due to extreme temperatures.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Don (Greg) Walker, Donald Yuhas, Mark Mutton, Peter Schmidt
Category:
Computer Science & Communications Diagnostics Thin Films & Nanomaterials

Cuffed Inner Cannula and Flexible Outer Cannula Tracheostomy Tube

This new tracheostomy tube design prevents the need for decannulation when changing from a cuffed to cuffless (or vice versa) tracheostomy. It also enables a comfortable and fit in patients with both large and small neck diameters. The tube enhances patient safety by maintaining the airway at all times when downsizing or upsizing.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Todd Dutton, Sanjay Athavale, Robert Webster
Category:
Medical Devices

Heterogeneous catalysis of NMR Signal Amplification by Reversible Exchange(SABRE)

Vanderbilt researchers have developed heterogeneous catalysis and catalyst for the NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization process. Coupled with the researchers' development of a method to perform SABRE in aqueous solutions, this discovery could allow fully biocompatible SABRE hyperpolarization processes in water with catalyst recycling. This would allow the production of pure aqueous contrast agents requiring only parahydrogen as a consumable.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Eduard Chekmenev, Boyd Goodson, Fan Shi, Aaron Coffey
Category:
Medical Imaging

Precision Pneumatic Robot for MRI-Guided Neurosurgery

At Vanderbilt University, a robotic steering mechanism for MRI-guided neurosurgical ablation has been developed. The small robot has submilimeter precision and is fully MRI compatible. It aims to replace current surgical practices with minimally invasive procedures in order to enhance the treatment of cancer and numerous neurological disorders such as epilepsy.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

David Comber, Eric Barth, Robert Webster, Hunter Gilbert
Category:
Medical Devices

PosiSeat(TM): Assured Seating of Threaded Surgical Components

Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

J Michael Fitzpatrick, Robert Labadie, Jason Mitchell
Category:
Medical Devices Medical Imaging

Actively Reconfigurable Metasurfaces for Dynamic Optical Components

Phase change materials (PCMs) are a fascinating class of materials that can change certain material properties (e.g., absorbance or reflectivity) upon the application of a stimulus. Researchers at Vanderbilt University have used a PCM to create a novel metamaterial that can be reconfigured for use in a wide range of potential optical and integrated photonic applications from the infrared to terahertz spectral domain.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Joshua Caldwell, Thomas Folland, Richard Haglund, Yohannes Abate
Category:
Thin Films & Nanomaterials

High Performance Nanofiltration Membranes

A research team led by Professor Shihong Lin at Vanderbilt University has developed a novel method to enhance the performance of nanofiltration (NF) membrane. This new approach has three major benefits:1) uses a class of additives that is low-cost and widely available2) is readily compatible with existing manufacturing infrastructure3) achieves ultra-sharp selectivity or enhanced perm-selectivity

Licensing Contact

Philip Swaney

615.322.1067
Category:
Agriculture & Environment Thin Films & Nanomaterials

Lanthanide Oxide Nanoparticle Film Deposition Process

Vanderbilt researchers have developed a method for forming a film of lanthanide oxide nanoparticles using electrophoretic deposition. This technique is straightforward to set up and provides thickness control at high deposition rates, enabling site selective particle assembly for any size and shape.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

James Dickerson, Sameer Mahajan
Category:
Thin Films & Nanomaterials

Porous Materials with Active Sites Created via In-Pore Synthesis

Vanderbilt researchers have synthesized porous adsorbent materials for the capture of toxic industrial chemicals. These adsorbent materials have finely dispersed reactive sites that allow for higher adsorption capacities than existing materials. They can be used in filters for the military, homeland security, first responders, and for a wide range of industrial and commercial catalysts to capture toxic gases such as ammonia and sulfur dioxide.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

M. Douglas LeVan, Dushyant Barpaga
Category:
General Engineering Thin Films & Nanomaterials