Browse Technologies

Displaying 71 - 80 of 267


Through the Tool Tracking for Friction Stir Welding

Utilizing force sensors mounted on the friction stir welding tool, Vanderbilt inventors have developed a technique to keep a weld tool on track. This technology is especially benefi cial in real time corrections for deviations in travel in the case of robotic FSW or ""blind"" welds. The technique is cost- effective in that no additional sensors such as cameras, thermocouples, acoustic emission receivers, etc. are required.


Licensing Contact

Ashok Choudhury

615.322.2503
Energy

Trackerless Image-Guidance Using a Surgical Microscope

Researchers at Vanderbilt have developed a new image-guided, trackerless surgical microscope system to be used in soft tissue surgeries. The current method is to use a surgical microscope along with an image-guided system. This new design eliminates the need for a separate image-guidance system; the entire guidance environment can be realized within the microscope environment.


Licensing Contact

Philip Swaney

615.322.1067

Inventors

Michael Miga

Transoral Lung Access Device

Transoral lung access is preferable to traditional needlebasedaccess due to the lower risk of lung collapse. However present bronchoscope-based devices enable access to only a small portion of the lung. The present device is a robotic image-guided bronchoscope to navigate the airway under closed-loop control to the target. IT is designed to provide transoral access to any location in the lung, particularly the hard-to-reach peripheral regions.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices

Ultrasonic Sensor for Non-intrusive Local Temperature, Transient Temperature and Heat Flux Measurements

An apparatus for measuring the temperature and heat flux of materials through the use of an ultrasonic sensor has been developed at Vanderbilt University. The sensor uses acoustic measurement techniques to determine the heat flux and temperature of material surfaces otherwise inaccessible in particular during system operation in order to enhance monitoring capabilities and reduce unsafe or impaired function due to extreme temperatures.


Licensing Contact

Ashok Choudhury

615.322.2503

Wireless Tablet Application for Remote Collaboration and Training in Colonoscopy

Colorectal cancer is the fourth leading cause of cancer-related mortality in the world. During patient screenings for populations at risk, polyp detection rates depend on the endoscopist's ability to identify the lesions, which takes years of practice and training. Endoscopic training can be challenging for the trainee and preceptor. Frustration can result from ineffective communication regarding areas of interest. Our team developed a novel tablet application for real-time mirroring of the colonoscopy examination that allows preceptors to make annotations directly on the viewing monitor that facilitates medical training and enables collaboration among several endoscopists during a procedure.


Licensing Contact

Masood Machingal

615.343.3548

New Insect Repellants Disrupt Olfactory Cues: A Strategy for Pest Protection

A multinational research team, led by Dr. L. J. Zwiebel of Vanderbilt University, has identified new compounds with potential as insect repellents. These compounds work by capitalizing on knowledge of how insect odorant receptors detect and respond to scents. Medicinal chemistry efforts have yielded a number of novel compounds that could short-circuit the insect olfactory system, essentially by over-stimulation, to effectively mask attractive odors. These compounds could be used to repel nuisance and disease-carrying insects away from humans and animals, as well as repel agricultural pests from crops or food storage facilities. Vanderbilt University is seeking commercial partners to develop the technology for agricultural uses.


Licensing Contact

Janis Elsner

615.343.2430

Small Molecule Theraputics That Target the Muscarinic Acetylcholine Receptor 1 For The Treatment of Alzheimer's Disease

The Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) has a mission to promote the translation of advances in basic science towards novel therapeutics. They have recruited faculty and staff with experience at over 10 different pharmaceutical companies to ensure a diverse set of approaches, techniques and philosophies to advancing compounds. Together they aim to de-risk drug discovery programs.


Licensing Contact

Tom Utley

615.343.3852
Therapeutics
Neuroscience/Neurology

Traveler's Diarrhea Vaccine for Enterotoxigenic E. coli (ETEC)

Vanderbilt researchers are developing a novel vaccine for preventing enterotoxigenic Escherichia coli (ETEC) infection of the gut which causes traveler's diarrhea and childhood death in developing countries. The vaccine uses colonization surface antigens and their constituent proteins to generate an immune response. This prevents infection by blocking the ability of bacteria to adhere to the intestinal mucosa. Mice treated with this vaccine showed significantly reduced disease and bacterial colonization compared to control. Preclinical development of this vaccine is ongoing and includes testing of different adjuvants and routes of administration. ETEC is a leading cause of gastrointestinal disease in developing countries affecting both residents and visitors. Residents in particular are primarily children who suffer high morbidity and mortality from the dehydrating effects of the illness. Visitors include the approximately 800 -- 1000 million people who travel to developing countries each year with 20 -- 60 % of them developing this illness. A commercially available vaccine to inoculate residents and travelers against ETEC would represent a significant opportunity to satisfy an unmet need and improve human health.


Licensing Contact

Jody Hankins

615.322.5907

Novel PLD Inhibitors

Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.


Licensing Contact

Karen Rufus

615.322.4295
Therapeutics

Two Degrees-of-Freedom, Fluid Power Stepper Actuator Model

Vanderbilt researchers have developed a novel technology for use of a flexible fluidic actuator in MRI-guided surgical systems. This method eliminates the need for moving the patient out of the MRI machine, onto an operating table, and back in order to perform procedures. It is a safe, sterilized, and successful method to simplify MRI-guided surgical procedures.


Licensing Contact

Taylor Jordan

615.936.7505