Browse Technologies

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Gratings on Porous Silicon Structures for Sensing Applications

In this technology diffraction-based sensors made from porous materials are used for the detection of small molecules. The porous nature of the diffraction gratings that gives rise to an extremely large active sensing area enables a very high level of sensitivity. Specificity is achieved by functionalizing the porous gratings with selective binding species.


Licensing Contact

Yiorgos Kostoulas

615.322.9790

The Adventures of Jasper Woodbury: Videodisc-Based Adventures That Focus on Mathematical Problem Finding and Problem Solving Designed for Students in Grades 5 and Up

The Adventures of Jasper Woodbury™ consists of 12 videodisc-based adventures that focus on mathematical problem finding and problem solving. In particular, each adventure provides multiple opportunities for problem solving, reasoning, communication and making connections to other areas such as science, social studies, literature and history. Jasper adventures are designed for students in grades 5 and up. Each videodisc contains a short (approximately 17 minute) video adventure that ends in a complex challenge. The adventures are designed like good detective novels where all the data necessary to solve the adventure (plus additional data that are not relevant to the solution) are embedded in the story. Jasper adventures also contain ""embedded teaching"" episodes that provide models of particular approaches to solving problems.


Licensing Contact

Janis Elsner

615.343.2430
Education

Composite Material for Tunable Memristance Behavior

This technology uses combinations of materials with different electronic properties of micro-or nanometerscale grain size to create a memristive device (twoterminal, variable resistance circuit element). Amidst growing interest in memristors, this technology is one of the first to use composite materials, which make the memristive qualities of the material tunable.


Licensing Contact

Ashok Choudhury

615.322.2503

Small Molecule mGlu3 NAMs as Therapeutics for CNS Disorders

The Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) has a mission to promote the translation of advances in basic science towards novel therapeutics. They have recruited faculty and staff with experience at over 10 different pharmaceutical companies to ensure a diverse set of approaches, techniques and philosophies to advancing compounds. Together they aim to de-risk drug discovery programs.


Licensing Contact

Tom Utley

615.343.3852
Therapeutics

On Chip Polarimetry for HTS

Using microfluidic technology developed by the Bornhop Lab at Vanderbilt, this invention enables the rapid determination of the optical activity of compounds and solutions. Due to the nature of this invention, it is possible to screen a multitude of samples in a high throughput manner in less time with less material and greater accuracy than the industry standards.


Licensing Contact

Janis Elsner

615.343.2430
Research Tools

Novel Target Regulating Angiogenesis

Vanderbilt scientists have discovered that the receptor tyrosine phosphatase DEP-1 plays a significant role in angiogenesis and that modulation of the DEP-1 receptor with certain agents can affect endothelial cell growth. The research team has developed antibodies that bind to the ectodomain of a mammalian transmembrane protein known as DEP-1 (for density enhanced protein) or CD148. CD148 (also named DEP-1/PTPn) is a receptor-like protein tyrosine phosphatase that is abundantly expressed in vascular endothelial cells, hematopoietic-cell lineages, duct epithelia of thyroid, mammary and gastrointestinal tissues.


Licensing Contact

Mike Villalobos

615.322.6751
Therapeutics

NanoBioReactor for Monitoring Small Cell Populations

NanoBioreactors recreate the microenvironments of normal tissue, non-adherent cells, tumor-infected tissue and wounded tissue in vitro. These microfabricated bioreactors provide independent control of chemokine and growth factor gradients, shear forces, cellular perfusion and the permeability of physical barriers to cellular migration. This fine control allows detailed optical and electrochemical observations of normal, immune and cancerous cells during activation, division, cell migration, intravasation, extravasation and angiogenesis.


Licensing Contact

Ashok Choudhury

615.322.2503
Microfluidics

mGlu3 NAMs as Therapeutics for Chemoresistant Tumors

Targeting metabotropic glutamate receptor 3 (mGlu3) has been linked as a potential therapeutic to many neurological disorders and well as oncology through the use of dual specific mGlu2/3 Antagonists (LY341495, RO4491533, MGS0039, RO4988546).


Licensing Contact

Tom Utley

615.343.3852
Therapeutics

High Inertance Liquid Piston Engine-Compressor

Inventors at Vanderbilt University have developed a high inertance engine-compressor for use with pneumatically actuated devices, especially those with periods of inactivity between periods of pneumatic use. It utilizes a flexible diaphragm in combination with a liquid piston to achieve high inertance and other operational features such as high efficiency, low noise and low temperature operation.


Licensing Contact

Taylor Jordan

615.936.7505
Energy

System and Methods of Using Image-guidance for Placement of Cochlear Stimulator Devices, Drug Carrier Devices, or the Like

Vanderbilt inventors have developed and tested a device (C-in) and method that would shift the current invasive, risky surgical procedure of cochlear implantation to a less invasive outpatient procedure.


Licensing Contact

Taylor Jordan

615.936.7505