Targeting metabotropic glutamate receptor 3 (mGlu3) has been linked as a potential therapeutic to many neurological disorders and well as oncology through the use of dual specific mGlu2/3 Antagonists (LY341495, RO4491533, MGS0039, RO4988546).
TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models
Vanderbilt researchers have developed an autofluorescence-based system for intraoperative margin assessment of pancreatic cancers. Also under development is the application of the same underlying technology to optimize pancreatic islet cell visualization and extraction to improve the efficiency of islet cell transplantation.
Vanderbilt researchers have developed a novel, extremely compact and lightweight device toprovide extracorporeal life support (ECLS) and membrane oxygenation (ECMO) in austere and militaryenvironments. Miniaturized in-line components allow for minimized materials and improved ease ofapplication in acute medical emergencies, especially in resource deprived conditions.
A team of Vanderbilt researchers has developed a novel system for producing 3D, real-time, high-resolution visualization within arms reach of a diver. The system uses a custom ultrasound array and mirror system in conjunction with software and algorithms to overcome the limitations of existing systems, enabling the diver to see through turbid water in real-time.
Vanderbilt researchers have developed a thermoresponsive filament material for use in 3D printing that can be readily dissolved via cooling. This material has use in a multitude of different applications. One potential application is lost-wax casting for tissue engineering. The present material enables the user to print an intricate vascular structure, embed the structure in an engineered tissue construct, and then dissolve the printed structure to create a hollow vascular network embedded within the tissue construct.
Vanderbilt researchers have developed a new system for transporting and sorting nanoscale and mesoscale particles and biomolecules. The system is able to achieve size-based sorting and captures/arranges the particles within a few seconds, which is significantly faster than the existing method of diffusion-based transport.