Targeting metabotropic glutamate receptor 3 (mGlu3) has been linked as a potential therapeutic to many neurological disorders and well as oncology through the use of dual specific mGlu2/3 Antagonists (LY341495, RO4491533, MGS0039, RO4988546).
TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models
Vanderbilt researchers have discovered a method ofmonitoring the placement of electrodes in cochlearimplants (CIs) through the use of electrical impedancemeasurements. This technology offers real-timefeedback on electrode positioning, which can beused to more accurately place electrodes duringinitial implantation, or better program the implantsafter they have been placed. These enhancementscombine to give increased hearing quality to bothnew and existing CI patients.
Vanderbilt researchers have developed a new system for transporting and sorting nanoscale and mesoscale particles and biomolecules. The system is able to achieve size-based sorting and captures/arranges the particles within a few seconds, which is significantly faster than the existing method of diffusion-based transport.
An assistive device for individuals with upper extremity neuromuscular deficit has been developed by researchers at Vanderbilt. This device is specifically designed for patients having hemiplegia following stroke, incomplete spinal cord injury, multiple sclerosis, and other disabilities and conditions, who may have severe muscle weakness or inability to fully control an upper limb. In order to facilitate use of the upper limb, the patient can wear the device as a substitute for or a supplement to the patient's volitional movement.
Vanderbilt researchers have developed a wearable surgical camera designed for use over the top of a surgical gown. The system, nicknamed Cleopatra, is designed specifically for the OR, maintains a consistent view of the operative field during a procedure, and is capable of supporting video, audio, lighting, and other technology in the immediate vicinity of the surgical field.
A new approach for obtaining less invasive optical measurements of the cervix has been developed that does not require the use of a speculum exam. This technology can visualize the cervix in vivo to find unique biomarkers that indicate various conditions such as preterm labor, cancer, human papillomavirus (HPV), and dysplasia.
Vanderbilt University researchers have developed self-destructing electrical conductors that dissolve and vanish below a certain critical temperature, which is achieved either by actively cooling the circuit or by removing a heat source.
A Vanderbilt University research team led by Professor John Wikswo has developed low-cost, small-volume, metering peristaltic micropumps and microvalves. These pumps and valves can be used either as stand-alone devices incorporated into microfluidic subsystems, or as readily customized components for research or miniaturized point-of-care instruments, Lab-on-a-Chip devices, and disposable fluid delivery cartridges.
Vanderbilt researchers have developed a continuum robot with the ability to adapt both its length and diameter of its segments. This could help expand the usability and effectiveness of continuum robots.