Targeting metabotropic glutamate receptor 3 (mGlu3) has been linked as a potential therapeutic to many neurological disorders and well as oncology through the use of dual specific mGlu2/3 Antagonists (LY341495, RO4491533, MGS0039, RO4988546).
TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models
Vanderbilt researchers have invented a modular microfluidic bioreactor that can be layered and stacked to create complex organ-on-chip systems that mimic the behavior of human organ systems such as the neurovascular unit. This modular device can also be assembled from separate, functioning biolayers, and at the end of a study disassembled for examination of individual cellular components.
A team of Vanderbilt engineers have developed a miniature magnetorheological (MR) brake with a combination of high braking torque and a fast response time. With potential applicability over a wide spectrum of applications, the device was initially developed with robotic and haptic applications in mind.
A team of Vanderbilt researchers has developed a novel system and method for non-destructive characterization of compound lenses. The approach uses optical coherence tomography and reflectance confocal microscopy to fully characterize lens geometry and glass materials, enabling accurate modeling of compound lenses.
Vanderbilt researchers have developed a technology for suppressing end-face reflections in most fiber optic components, thereby reducing a significant source of noise in fiber-optic systems. The solution employs a fused-spliced length of angle-polished no-core fiber in order to angle reflections outside the acceptance numerical aperture of the fiber and spatially offsetting any reflections to minimize back-coupling. The result is a compact solution that significant decreases noise without significantly altering the specifications of the fiber-optic component.
A team of Vanderbilt researchers has developed a novel system for producing 3D, real-time, high-resolution visualization within arms reach of a diver. The system uses a custom ultrasound array and mirror system in conjunction with software and algorithms to overcome the limitations of existing systems, enabling the diver to see through turbid water in real-time.
A team of Vanderbilt researchers has developed a novel fiducial marker for use during radiosurgery of the eye. The fiducial is a non-invasive, comfortable method for performing registration of preoperative medical images and the radiotherapy target during therapy. The device aims to remove the need for existing invasive registration procedures, while still providing accurate localization to the clinician.
Vanderbilt researchers have discovered a method ofmonitoring the placement of electrodes in cochlearimplants (CIs) through the use of electrical impedancemeasurements. This technology offers real-timefeedback on electrode positioning, which can beused to more accurately place electrodes duringinitial implantation, or better program the implantsafter they have been placed. These enhancementscombine to give increased hearing quality to bothnew and existing CI patients.