Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.
This genetic test identifies cattle at high risk of developing pulmonary hypertension at high altitudes (often called "brisket disease"). Brisket disease afflicts about 5% of cattle at high altitudes and the current predictive test for at-risk cattle is a measure of pulmonary arterial pressure (PAP). This current PAP test has some major drawbacks. First, it is an invasive test. Secondly, it is not accurate at lower elevations -- so at-risk cattle cannot identified before incurring the cost of transport to high altitude. There is no treatment for the disease except prompt removal of the animal to lower elevations. This technology measures genetic variants that confer susceptibility to brisket disease, and could be developed into a diagnostic or a prognostic test for use prior to shipping cattle to higher elevations or in breeding operations.
Vanderbilt researchers have developed a novel technology for use of a flexible fluidic actuator in MRI-guided surgical systems. This method eliminates the need for moving the patient out of the MRI machine, onto an operating table, and back in order to perform procedures. It is a safe, sterilized, and successful method to simplify MRI-guided surgical procedures.
The Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) has a mission to promote the translation of advances in basic science towards novel therapeutics. They have recruited faculty and staff with experience at over 10 different pharmaceutical companies to ensure a diverse set of approaches, techniques and philosophies to advancing compounds. Together they aim to de-risk drug discovery programs.
Vanderbilt researchers have designed a general purpose system for precise steering of multi-lumen needles. One significant application of the system is decompression of the cranium during hemorrhagic events (ICH).
A new phantom has been designed in which Doppler ultrasound measurements can be conducted for quality assurance purposes. The phantom is highly portable, does not require power to operate, and allows for simple and reproducible measurements of Doppler ultrasound function. This combination of advantages allows for realistic monthly, weekly, even daily Doppler QA measurements.
Vanderbilt researchers have developed a novel system for allowing surgical instruments to navigate around tighter corners and access difficult-to-reach areas in the body. This system uses pre-curved elastic elements added on to the existing instrument. Current surgical instruments are manufactured in a straight-line configuration, which means they must bend in order to reach around obstructions in surgery. By adding pre-curved sections, some of the bending is already accomplished, allowing the instrument to bend around tighter corners.
Vanderbilt researchers have designed a forward scanning miniature intraoperative Optical Coherence Tomography (OCT) probe that can be used for diagnostic purposes and real-time monitoring of surgery within small spaces, such as endoscopic surgery, intraocular surgery, and other microsurgery.