Browse Technologies

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A Robotic System for Treating Intracranial Hemorrhage (ICH)

Vanderbilt researchers have designed a general purpose system for precise steering of multi-lumen needles. One significant application of the system is decompression of the cranium during hemorrhagic events (ICH).


Licensing Contact

Ashok Choudhury

615.322.2503

Vascular Restoration Therapy with Cell-Penetrating CRADD Protein

Vascular inflammation caused by metabolic, autoimmune, and microbial insults mediates cardiovascular diseases that include hypertension and atherosclerosis (heart attacks, strokes), systemic lupus, and giant cell arteritis. An estimated 35 million Americans have hypercholesterolemia, contributing to 500,000 deaths underlying heart attacks and strokes. In these diseases, metabolic, autoimmune, and microbial insults continually challenge blood and vascular cells by triggering signaling to the nucleus mediated by BCL10. Genetic ablation of BCL10 rescues animals from atherosclerosis, aortic aneurysms, and fatty liver and insulin resistance due to overnutrition. Intracellular therapy with CP-CRADD is designed to extinguish BCL10-mediated noxious signals to avert vascular inflammation and its life-threatening complications including ruptured aneurysms in aorta and brain.


Licensing Contact

Janis Elsner

615.343.2430
Therapeutics

Prognostic Assay for High-altitude Pulmonary Hypertension in Cattle (Brisket Disease)

This genetic test identifies cattle at high risk of developing pulmonary hypertension at high altitudes (often called "brisket disease").  Brisket disease afflicts about 5% of cattle at high altitudes and the current predictive test for at-risk cattle is a measure of pulmonary arterial pressure (PAP).  This current PAP test has some major drawbacks.  First, it is an invasive test.  Secondly, it is not accurate at lower elevations -- so at-risk cattle cannot identified before incurring the cost of transport to high altitude.  There is no treatment for the disease except prompt removal of the animal to lower elevations.  This technology measures genetic variants that confer susceptibility to brisket disease, and could be developed into a diagnostic or a prognostic test for use prior to shipping cattle to higher elevations or in breeding operations.


Licensing Contact

Jody Hankins

615.322.5907

Higher Accuracy Image-Guidance in Surgery

Vanderbilt engineers have designed and built a device that improves the accuracy of image-guidance systems (IGS) during surgery. The device creates a custom,  non-slip fit over the head and provides a rigid platform for attaching optical tracking markers to the patient, which is a critical component of image-guided neurosurgical procedures. The device can be used to improve the accuracy of IGS in other areas of the anatomy as well.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices

A Simple and Highly Portable Flow Phantom for Doppler Ultrasound Quality Measurements

A new phantom has been designed in which Doppler ultrasound measurements can be conducted for quality assurance purposes. The phantom is highly portable, does not require power to operate, and allows for simple and reproducible measurements of Doppler ultrasound function. This combination of advantages allows for realistic monthly, weekly, even daily Doppler QA measurements.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Agriculture: Control of Insect Populations via Wolbachia or Bacteriophage Tools

The insect microbiome is a rich resource that can explored to control insect reproduction and insect populations at large. Vanderbilt University has a collection of technologies available for such purposes, including bacteriophage therapies, Wolbachia genomic editing techniques and tools, and transgenic insect approaches.


Licensing Contact

Jody Hankins

615.322.5907

Animal Health: Control of Insect Populations via Wolbachia or Bacteriophage Tools

The insect microbiome is a rich resource that can explored to control insect reproduction and insect populations at large. Vanderbilt University has a collection of technologies available for such purposes, including bacteriophage therapies, Wolbachia genomic editing techniques and tools, and transgenic insect approaches.


Licensing Contact

Jody Hankins

615.322.5907

Breast Tumor Margin Detection System Using Spatially Offset Raman Spectroscopy

Vanderbilt University researchers have developed a technology that uses spatially offset Raman spectroscopy to obtain depth-resolved information from the margins of tumors. This helps to determine positive or negative tumor margins in applications such as breast lumpectomy, and the technology is currently being investigated for breast cancer margin detection.


Licensing Contact

Ashok Choudhury

615.322.2503

Bright White Light Nanocrystals for LEDs

A research team lead by Professor Sandra Rosenthal at Vanderbilt University has developed nanocrystals (~2 nm diameter) that emit white light with very high quantum efficiency. This technology would be a viable cost effective candidate for commercial solid-state lighting applications, such as Light Emitting Diodes (LEDs). These nanocrystals were originally discovered by the same group in 2005; a recent breakthrough in post-treatment results in improving fluorescent quantum yield up to ~ 45%.


Licensing Contact

Chris Harris

615.343.4433

Compliant Insertion, Motion, and Force Control of Continuum Robots

Vanderbilt researchers have developed a framework for compliant insertion with hybrid motion and force control of continuum robots. This technology expands the capabilities of robotic surgery by providing continuum robots with the ability to autonomously discern, locate, and react to contact along their length and calculate forces at the tip, thus enabling quick and safe deployment of snake-like robots into deep anatomical passages or unknown environments.


Licensing Contact

Masood Machingal

615.343.3548