Browse Technologies

Displaying 151 - 160 of 207


Antimicrobial Compounds and Methods of Use Thereof

Vanderbilt researchers, led by Eric Skaar, Ph.D., have identified novel compounds that are antimicrobial. These compounds represent a first in class as they target a new bacterial pathway that has never been targeted as an antimicrobial strategy.


Licensing Contact

Karen Rufus

615.322.4295
Therapeutics

Catheter Having Temperature Controlled Anchor and Related Methods

Heart valve disease is the 3rd most prevalent source of cardiovascular disease, leading to approximately 20,000 deaths per year in the U.S. alone. Moreover, there are an estimated 41,000 mitral valve procedures performed in the U.S. each year. The only effective, long-term treatment for mitral valve disease is open-chest valve replacement surgery, which is highly undesirable for elderly patients. Thus, there is a pressing need to develop novel percutaneous strategies for treatment that will reduce the number of open-chest surgeries. David Merryman and colleagues have developed a new, combined catheter that uses cryo temperatures to adhere to moving mitral valve leaflets and radiofrequency ablation to alter the compliance of the leaflet tissue to prevent prolapse and regurgitation.


Licensing Contact

Taylor Jordan

615.936.7505
Medical Devices

PANORAMIC: Precession and Nutation for Observing Rotation at Multiple Intervals about the Carrier

Methods of hyperpolarization based on parahydrogen have been expanding recently from the early applications in hydrogenation chemistry to biomedical imaging where they are expected to yield similar information as the competing technology, dynamic nuclear polarization, (DNP). These hyperpolarization experiments have already enabled the measurement of metabolism in vivo at temporal resolutions of seconds. When infused into organisms harboring tumor cells, molecules such as pyruvate and lactate have been shown to be sufficiently long-lived to infiltrate cellular metabolic cycles and be converted at different rates in cancer versus normal tissue. DNP has been used most frequently in these early studies, owing to commercial availability and the flexibility to polarize small molecules such as pyruvate and lactate. Techniques based on chemical addition or exchange of parahydrogen have also shown promise for generating metabolic contrast in vivo at similar levels of signal enhancement and at lower costs.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Medical Imaging

Porous Silicon Membrane Waveguide Biosensor

Vanderbilt researchers have developed a low-cost, high sensitivity sensor based on a porous silicon (PSi) membrane waveguide. This sensor is designed to be a cost-effective alternative to conventional fiber optic and SPR sensors for both biosensing and chemical sensing applications.


Licensing Contact

Yiorgos Kostoulas

615.322.9790

Cleavable Surfactants for the Analysis of Proteins and Other Biological and Chemical Samples


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Mass Spectrometry Tools

Screening Assay for Molecules That Alter Cell Cycle Rhythm

This research targets Cell Cycle.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Assays/Screening
Oncology Research Reagent

Mice with Inducible Cre-ERt Replacing Cytokeratin 19 Coding Region

This research targets CK19.


Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Guoqiang Gu, Anna Means
Research Tools
Animal Model
Oncology

Slc5a7 (choline transporter, CHT) BAC Transgenic Mouse

A Bacterial Artificial Chromosome (BAC) containing the mouseSlc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Randy Blakely
Research Tools
Animal Model

Recombinant Human Sodium Channel Nav1.5 with Long-QT Syndrome (LQT3) Mutations

Mammalian expression plasmids encoding mutant human voltage-gated sodium channel (NaV1.5) cDNA for use in heterologous expression studies. The plasmids encode versions of NaV1.5 with specific mutations identified in patients with congenital long-QT syndrome type 3 (LQT3 mutations).


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Nucleic Acid/Plasmid

Metabolic Labeling Reagents for Chondroitin Sulfate

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans. These stunning images demonstrate incorporation of these metabolic labeling reagents to track neurodevelopmental processes in a zebrafish model system. Notably, the metabolic label can be detected post vivo using a standard ""click"" chemistry reaction. Further, Dr. Page-McCaw has optimized a background reduction strategy to complement this technology by improving the signal-to-noise ratio.


Licensing Contact

Mike Villalobos

615.322.6751
Research Tools
Imaging
Research Reagent