Browse Technologies

Displaying 121 - 130 of 238


Non-Invasive Cell Size Detection

Vanderbilt researchers have developed a new method for using contrast enhanced MRI to non-invasively map and quantify cell size on a voxel-by-voxel basis. Using this approach, it is possible to monitor and detect diseases or treatments that alter the distribution of cell sizes such as cancer, muscular dystrophy, hepatocellular hypertrophy, and hypertrophic cardiomyopathy.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Parahydrogen-Induced Polarizer (PHIP)

The present invention provides a PANACEA (Pneumatics Allow Nonmagnetic Actuation for Creation of Enhanced Alignment) polarizer system. This is an integrated assembly of pneumatically actuated, nonmagnetic hydraulic circuits that enable PASADENA chemicals to be efficiently stored, mixed, and reacted in close proximity or within NMR magnetic fields.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Medical Imaging

Porous Materials with Active Sites Created via In-Pore Synthesis

Vanderbilt researchers have synthesized porous adsorbent materials for the capture of toxic industrial chemicals. These adsorbent materials have finely dispersed reactive sites that allow for higher adsorption capacities than existing materials. They can be used in filters for the military, homeland security, first responders, and for a wide range of industrial and commercial catalysts to capture toxic gases such as ammonia and sulfur dioxide.


Licensing Contact

Philip Swaney

615.322.1067

Real-time Detection of Position and Orientation of Wireless Endoscopy Capsule using Magnetic coupling

Vanderbilt researchers have developed a new system to detect the position, orientation, and pressure exerted on surrounding tissues of a wireless capsule endoscopy device.  Magnetic coupling is one of the few physical phenomena capable of transmitting actuation forces across a physical barrier.  Magnetic manipulation has the potential to make surgery less invasive, by allowing untethered miniature devices to enter the body through natural orifices or tiny incisions, and then maneuver with minimal disruption to healthy tissue.  In order to accomplish this goal, the pose (position and orientation) of the medical device must be available in real time.


Licensing Contact

Masood Machingal

615.343.3548

Relaxation Time Discriminated 1H NMR for Bone Mechanical/Fracture Property Diagnostics

Advances in modern MRI pulse sequences, including ultrashort-echo time and related MRI methods for imaging short T2 signals, have enabled clinically-practical cortical bone imaging. Researchers at the Vanderbilt University Institute of Imaging Science have developed a method of distinguishing and quantifying nuclear magnetic resonance (NMR) signals for cortical bone analysis.


Licensing Contact

Chris Harris

615.343.4433

Selective Size Imaging using Filters via Diffusion Times (SSIFT)

Vanderbilt researchers have developed a novel MRI-based method for fast, robust, and accurate imaging of biological tissue by selecting a specific cell size range (such as tumors) without the need for a contrast agent. One exciting application of this method is imaging brain metastases (BM) that are difficult to differentiate from other brain abnormalities such as radionecrosis when using existing approaches.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Junzhong Xu
Medical Imaging

Single Stage, High Performance Transmission Mechanism

A researcher from Vanderbilt University has created a novel single stage transmission with a high transmission ratio that was born from the physics of a coin wobbling as it rolls on a table. This innovation offers a great advantage over existing single stage transmissions in terms of a smaller and lighter weight design, increased efficiency, and a reduction in manufacturing cost.


Licensing Contact

Ashok Choudhury

615.322.2503

Small Molecule-GIRK Potassium Channel Modulators That Are Anxiolytic Therapeutics

The G-protein activated, inward-rectifying potassium (K+) channels, "GIRKs", are a family of ion channels that has been the focus of intense research interest for nearly two decades. GIRK has been shown to play important roles in the pathophysiology of diseases such as anxiety, epilepsy, Down's syndrome, pain perception and drug addiction. Here scientists at Vanderbilt developed the first truly potent, effective, and selective GIRK activator, ML297 (VU0456810) and demonstrated that ML297 is active in animal models of epilepsy. While the group is using ML297 to continue to explore the therapeutic benefits of GIRK modulation, they are continuing to develop more selective and druggable GIRK inhibitors from different scaffolds.


Licensing Contact

Tom Utley

615.343.3852
Therapeutics
Analgesic

Surface Active Ionic Liquid with Activity in Aqueous and Non-aqueous Media

Surface active ionic liquids (SAILs) exhibit extraordinary properties both as solvents and superior surfactants. However, existing SAILs have limitations that prevent their full potential from being realized. To address this, researchers at Vanderbilt have synthesized a promising chiral SAIL that can be used as a detergent or stabilizing agent at all kinds of interfaces and is made from an inexpensive and biodegradable starting material.


Licensing Contact

Masood Machingal

615.343.3548

Synthesis and Characterization of New Terpolymers

Vanderbilt researchers have developed a novel method for synthesizing a new class of terpolymers with tunable mechanical and chemical properties for coronary stent applications.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices