Browse Technologies

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New Clostridium Difficile Recombinant Toxin for Safe Vaccine Development

A structural biology approach has identified a conserved region common to multiple Clostridium toxins. Specific mutations of the protein sequence in this region prevent the toxins from entering into intestinal cells, thereby preventing widespread tissue damage. These recombinant Clostridium toxins may be used to create a multivalent vaccine to protect against multiple species of Clostridium. Furthermore, the recombinant toxin may be used as a safer alternative to the native toxins in vaccine manufacturing. This discovery stems from a collaboration between the laboratories of Dr. Borden Lacy of Vanderbilt University and Dr. Roman Melnyk of the Hospital for Sick Children.


Licensing Contact

Seema Sinha

615.343.2430

New Insect Repellants Disrupt Olfactory Cues: A Strategy for Pest Protection

A multinational research team, led by Dr. L. J. Zwiebel of Vanderbilt University, has identified new compounds with potential as insect repellents. These compounds work by capitalizing on knowledge of how insect odorant receptors detect and respond to scents. Medicinal chemistry efforts have yielded a number of novel compounds that could short-circuit the insect olfactory system, essentially by over-stimulation, to effectively mask attractive odors. These compounds could be used to repel nuisance and disease-carrying insects away from humans and animals, as well as repel agricultural pests from crops or food storage facilities. Vanderbilt University is seeking commercial partners to develop the technology for agricultural uses.


Licensing Contact

Seema Sinha

615.343.2430

Agriculture: Control of Insect Populations via Wolbachia or Bacteriophage Tools

The insect microbiome is a rich resource that can explored to control insect reproduction and insect populations at large. Vanderbilt University has a collection of technologies available for such purposes, including bacteriophage therapies, Wolbachia genomic editing techniques and tools, and transgenic insect approaches.


Licensing Contact

Clarissa Muere

615.343.2430

Animal Health: Control of Insect Populations via Wolbachia or Bacteriophage Tools

The insect microbiome is a rich resource that can explored to control insect reproduction and insect populations at large. Vanderbilt University has a collection of technologies available for such purposes, including bacteriophage therapies, Wolbachia genomic editing techniques and tools, and transgenic insect approaches.


Licensing Contact

Clarissa Muere

615.343.2430

New antibiotics against new targets in multi-drug resistant microorganisms

New everninomicin antibiotics including a potent bifunctional antibiotic natural product targeting two different and distant ribosomal sites are under development and can be readily produced using synthetic biology. Developing resistance to this bidentate antibiotic should be very difficult for pathogenic microorganisms.


Licensing Contact

Clarissa Muere

615.343.2430
Therapeutics
Infectious Disease

New Drug for Blood Clot: FXII Inhibitors to Treat Thrombosis

Thrombosis is the formation of a blood clot inside a blood vessel, which may cause reduced blood flow to a tissue, or even tissue death. Thrombosis, inflammation, and infections are responsible for >70% of all human mortality. Thrombosis is also the major factor for heart disease and stroke. 500,000 die from thrombosis every year in Europe. Inhibitory treatment of these conditions may also improve the outcomes of several non-fatal diseases. Researchers from Vanderbilt University and Oregon Health & Science University have jointly discovered new monoclonal antibodies that potently inhibit the blood coagulation protein factor XII (FXII), a critical player in the pathway, and anticoagulate blood. This invention provides foundation for commercial development of anti-thrombotic drugs based on new molecular entities.


Licensing Contact

Clarissa Muere

615.343.2430
Therapeutics

The Adventures of Jasper Woodbury: Videodisc-Based Adventures That Focus on Mathematical Problem Finding and Problem Solving Designed for Students in Grades 5 and Up

The Adventures of Jasper Woodbury™ consists of 12 videodisc-based adventures that focus on mathematical problem finding and problem solving. In particular, each adventure provides multiple opportunities for problem solving, reasoning, communication and making connections to other areas such as science, social studies, literature and history. Jasper adventures are designed for students in grades 5 and up. Each videodisc contains a short (approximately 17 minute) video adventure that ends in a complex challenge. The adventures are designed like good detective novels where all the data necessary to solve the adventure (plus additional data that are not relevant to the solution) are embedded in the story. Jasper adventures also contain ""embedded teaching"" episodes that provide models of particular approaches to solving problems.


Licensing Contact

Peter Rousos

615.343.4465
Education

Systems-Biology Infrastructure to Identify Drug Repurposing Opportunities as Antiviral & Anticancer Therapeutics

Vanderbilt researchers have developed an in-silico screening method to reveal new indications for existing drugs with known protein targets using a novel infrastructure. The infrastructure integrates multiple factors across system-biology models to create a drug discovery pipeline.


Licensing Contact

Clarissa Muere

615.343.2430

Vascular Restoration Therapy with Cell-Penetrating CRADD Protein

Vascular inflammation caused by metabolic, autoimmune, and microbial insults mediates cardiovascular diseases that include hypertension and atherosclerosis (heart attacks, strokes), systemic lupus, and giant cell arteritis. An estimated 35 million Americans have hypercholesterolemia, contributing to 500,000 deaths underlying heart attacks and strokes. In these diseases, metabolic, autoimmune, and microbial insults continually challenge blood and vascular cells by triggering signaling to the nucleus mediated by BCL10. Genetic ablation of BCL10 rescues animals from atherosclerosis, aortic aneurysms, and fatty liver and insulin resistance due to overnutrition. Intracellular therapy with CP-CRADD is designed to extinguish BCL10-mediated noxious signals to avert vascular inflammation and its life-threatening complications including ruptured aneurysms in aorta and brain.


Licensing Contact

Clarissa Muere

615.343.2430
Therapeutics

Dexterous Robotic Wrist and Gripper for Extreme Precision Micro-surgical Maneuvers in Confined Spaces

This invention presents a robotic wrist and gripper that operate with three independent degrees of freedom (yaw, pitch and roll) for increased dexterity in minimally invasive surgical procedures. This is the smallest robotic wrist of its kind, and due to its size and unparalleled dexterity, this wrist enables complex surgical maneuvers for minimally invasive procedures in highly confined spaces. Examples of surgical areas benefiting from use of this wrist include natural orifice surgery, single port access surgery, and minimally invasive surgery. In particular, the proposed wrist allows for very high precision roll about the longitudinal axis of the gripper while overcoming problems of run-out motion typically encountered in existing wrists. Thus this wrist is particularly suitable for extreme precision maneuvers for micro-surgery in confined spaces.


Licensing Contact

Masood Machingal

615.343.3548
Medical Devices