Browse Technologies

Displaying 11 - 20 of 238


I-Wire: A Biotension Measurement Device for Tissue Engineering and Pharmacology

Vanderbilt researchers have developed an integrated system ("I-Wire") for the growth of miniature, engineered 3D cardiac or other muscle or connective tissues and their active and passive mechanical characterization. The system utilizes an inverted microscope to measure the strain when the tissue constructs are laterally displaced using a calibrated flexible cantilevered probe.


Licensing Contact

Ashok Choudhury

615.322.2503

Multisubstrate Inhibitors of Histone Acetylation Increase the Cytotoxicity of Chemotherapeutic Agents

Inhibitors of histone acetylation may constitute a novel class of potent therapy sensitizers applicable to a broad range of conventional cancer treatments.


Licensing Contact

Mike Villalobos

615.322.6751
Therapeutics
Oncology

PosiSeat(TM): Assured Seating of Threaded Surgical Components

Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest.


Licensing Contact

Taylor Jordan

615.936.7505

Portfolio of Image-Guidance and Organ Localization Technologies from the Lab of Professor Michael Miga

The focus of Dr. Miga's laboratory is on the development of new paradigms in detection, diagnosis, characterization, and treatment of disease through the integration of computational models into research and clinical practice.


Licensing Contact

Philip Swaney

615.322.1067

Image Guidance System for Breast Cancer Surgery

Vanderbilt researchers have developed an image guidance system that aims to reduce the revision rate for breast conserving surgeries through the use of intraoperative tumor location. The platform integrates MRI imaging, optical tracking, tracked ultrasound, and patient specific biomechanical models to provide a superior tumor localization end result.


Licensing Contact

Philip Swaney

615.322.1067

Continuum Robots with Equilibrium Modulation (CREM)

The A.R.M.A. Laboratory of Vanderbilt University has developed a novel continuum robot design enabling multi-scale motion at the macro and micro scale. The unique design allows miniaturization with minimal added cost thereby potentially giving rise to a new generation of surgical robots capable of both macro-motion for surgical intervention and micro-scale motion for cellular-level imaging or intervention. Micro-motion is achieved through a unique method for altering the equilibrium pose of the robot via material re-distribution throughout the length of the robot. This process ushers in a new class of surgical robotics termed continuum robots with equilibrium modulation (CREM).


Licensing Contact

Masood Machingal

615.343.3548
Medical Devices

Portfolio of Continuum Robotic Systems, Algorithms, and Software Technologies from the Robotics Lab of Professor Nabil Simaan

Professor Simaan and his lab have years of experiencing working collaboratively with commercial entities of various sizes. His research is focused on advanced robotics, mechanism design, control, and telemanipulation for medical applications. His projects have led the way in advancing several robotics technologies for medical applications including high dexterity, snake-like robots for surgery, steerable electrode arrays for cochlear implant surgery, robotics for single port access surgery, and natural orifice surgery.


Licensing Contact

Masood Machingal

615.343.3548
Medical Devices
Genitourinary

A Robotic System for Treating Intracranial Hemorrhage (ICH)

Vanderbilt researchers have designed a general purpose system for precise steering of multi-lumen needles. One significant application of the system is decompression of the cranium during hemorrhagic events (ICH).


Licensing Contact

Ashok Choudhury

615.322.2503

Vascular Restoration Therapy with Cell-Penetrating CRADD Protein

Vascular inflammation caused by metabolic, autoimmune, and microbial insults mediates cardiovascular diseases that include hypertension and atherosclerosis (heart attacks, strokes), systemic lupus, and giant cell arteritis. An estimated 35 million Americans have hypercholesterolemia, contributing to 500,000 deaths underlying heart attacks and strokes. In these diseases, metabolic, autoimmune, and microbial insults continually challenge blood and vascular cells by triggering signaling to the nucleus mediated by BCL10. Genetic ablation of BCL10 rescues animals from atherosclerosis, aortic aneurysms, and fatty liver and insulin resistance due to overnutrition. Intracellular therapy with CP-CRADD is designed to extinguish BCL10-mediated noxious signals to avert vascular inflammation and its life-threatening complications including ruptured aneurysms in aorta and brain.


Licensing Contact

Janis Elsner

615.343.2430
Therapeutics

Prognostic Assay for High-altitude Pulmonary Hypertension in Cattle (Brisket Disease)

This genetic test identifies cattle at high risk of developing pulmonary hypertension at high altitudes (often called "brisket disease").  Brisket disease afflicts about 5% of cattle at high altitudes and the current predictive test for at-risk cattle is a measure of pulmonary arterial pressure (PAP).  This current PAP test has some major drawbacks.  First, it is an invasive test.  Secondly, it is not accurate at lower elevations -- so at-risk cattle cannot identified before incurring the cost of transport to high altitude.  There is no treatment for the disease except prompt removal of the animal to lower elevations.  This technology measures genetic variants that confer susceptibility to brisket disease, and could be developed into a diagnostic or a prognostic test for use prior to shipping cattle to higher elevations or in breeding operations.


Licensing Contact

Jody Hankins

615.322.5907