Browse Technologies

Displaying 11 - 20 of 257


Traveler's Diarrhea Vaccine for Enterotoxigenic E. coli (ETEC)

Vanderbilt researchers are developing a novel vaccine for preventing enterotoxigenic Escherichia coli (ETEC) infection of the gut which causes traveler's diarrhea and childhood death in developing countries. The vaccine uses colonization surface antigens and their constituent proteins to generate an immune response. This prevents infection by blocking the ability of bacteria to adhere to the intestinal mucosa. Mice treated with this vaccine showed significantly reduced disease and bacterial colonization compared to control. Preclinical development of this vaccine is ongoing and includes testing of different adjuvants and routes of administration. ETEC is a leading cause of gastrointestinal disease in developing countries affecting both residents and visitors. Residents in particular are primarily children who suffer high morbidity and mortality from the dehydrating effects of the illness. Visitors include the approximately 800 -- 1000 million people who travel to developing countries each year with 20 -- 60 % of them developing this illness. A commercially available vaccine to inoculate residents and travelers against ETEC would represent a significant opportunity to satisfy an unmet need and improve human health.


Licensing Contact

Jody Hankins

615.322.5907

Flat-Cut Bit for Cranial Perforator

Inventors at Vanderbilt have developed a novel perforating drill bit for cranial surgery. Deep brain stimlation (DBS) has become a technique for the treatment of movement disorders, as well as obsessive compulsive disorders and epilespy. This cranial drill bit significantly improves the process of preparing the periphery around the cranial punch during electrode implantation, one of the critical steps during DBS surgery.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices

System and Methods for Contact Detection and Localization in Continuum Robots

This technology expands the capabilities of continuum robots with a system and method that enables them to detect instances of contact and to estimate the position of the contact. This framework allows the motion of the robot to be constrained so as to ensure the robot doesn't damage itself, another robot arm, or surrounding environments. Applications for this technology include enhanced safe telemanipulation for multi-arm continuum robots in surgery, micro-assembly in confined spaces, and exploration in unknown environments.


Licensing Contact

Masood Machingal

615.343.3548

Minimally Invasive Telerobotic Platform for Transurethral Exploration and Intervention

This technology, developed in Vanderbilt University's Advanced Robotics and Mechanism Applications Laboratory, uses a minimally invasive telerobotic platform to perform transurethral procedures, such as transurethral resection. This robotic device provides high levels of precision and dexterity that improve patient outcomes in transurethral procedures.


Licensing Contact

Masood Machingal

615.343.3548
Medical Devices
Genitourinary

Compliant Insertion, Motion, and Force Control of Continuum Robots

Vanderbilt researchers have developed a framework for compliant insertion with hybrid motion and force control of continuum robots. This technology expands the capabilities of robotic surgery by providing continuum robots with the ability to autonomously discern, locate, and react to contact along their length and calculate forces at the tip, thus enabling quick and safe deployment of snake-like robots into deep anatomical passages or unknown environments.


Licensing Contact

Masood Machingal

615.343.3548

Continuum Robots with Equilibrium Modulation (CREM)

The A.R.M.A. Laboratory of Vanderbilt University has developed a novel continuum robot design enabling multi-scale motion at the macro and micro scale. The unique design allows miniaturization with minimal added cost thereby potentially giving rise to a new generation of surgical robots capable of both macro-motion for surgical intervention and micro-scale motion for cellular-level imaging or intervention. Micro-motion is achieved through a unique method for altering the equilibrium pose of the robot via material re-distribution throughout the length of the robot. This process ushers in a new class of surgical robotics termed continuum robots with equilibrium modulation (CREM).


Licensing Contact

Masood Machingal

615.343.3548
Medical Devices

Methods for Quick and Safe Deep Access into Mammalian Anatomy

This technology uses a novel continuum robot that provides a steerable channel to enable safe surgical access to the anatomy of a patient. This robotic device has a wide range of clinical application and is a significant advance from the rigid tools currently used in minimally invasive procedures.


Licensing Contact

Masood Machingal

615.343.3548
Robotics

Smart Battery Controller with Fault Tolerance

Vanderbilt researchers have developed a smart controller that intelligently reconfigures a battery bank to both extend the overall discharge time and provide fault tolerance.


Licensing Contact

Chris Harris

615.343.4433

Point of Care Rheological Assay for Sickle Cell Disease

Vanderbilt researchers have created a novel technology for the diagnosis and monitoring of disease states using the rheological properties of a blood sample with a lateral flow membrane.


Licensing Contact

Ashok Choudhury

615.322.2503

Dexterous Robotic Wrist and Gripper for Extreme Precision Micro-surgical Maneuvers in Confined Spaces

This invention presents a robotic wrist and gripper that operate with three independent degrees of freedom (yaw, pitch and roll) for increased dexterity in minimally invasive surgical procedures. This is the smallest robotic wrist of its kind, and due to its size and unparalleled dexterity, this wrist enables complex surgical maneuvers for minimally invasive procedures in highly confined spaces. Examples of surgical areas benefiting from use of this wrist include natural orifice surgery, single port access surgery, and minimally invasive surgery. In particular, the proposed wrist allows for very high precision roll about the longitudinal axis of the gripper while overcoming problems of run-out motion typically encountered in existing wrists. Thus this wrist is particularly suitable for extreme precision maneuvers for micro-surgery in confined spaces.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices