Research Tools

Displaying 51 - 60 of 67


New Insect Repellants Disrupt Olfactory Cues: A Strategy for Pest Protection

A multinational research team, led by Dr. L. J. Zwiebel of Vanderbilt University, has identified new compounds with potential as insect repellents. These compounds work by capitalizing on knowledge of how insect odorant receptors detect and respond to scents. Medicinal chemistry efforts have yielded a number of novel compounds that could short-circuit the insect olfactory system, essentially by over-stimulation, to effectively mask attractive odors. These compounds could be used to repel nuisance and disease-carrying insects away from humans and animals, as well as repel agricultural pests from crops or food storage facilities. Vanderbilt University is seeking commercial partners to develop the technology for agricultural uses.


Licensing Contact

Janis Elsner

615.343.2430

A Method for Genetically Engineering Proteins with Cell Membrane Translocating Activity

The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.


Licensing Contact

Janis Elsner

615.343.2430
Research Tools

Cleavable Surfactants for the Analysis of Proteins and Other Biological and Chemical Samples


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Mass Spectrometry Tools

Integrated Device for Leaching Extraction and Assessment

The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents with low aqueous solubility.


Licensing Contact

Chris Harris

615.343.4433
Research Tools

Lipoxygenase Proteins and Nucleic Acids

Isolated and purified lipoxygenase proteins and nucleic acids are described. Particularly, a novel human 15(S) lipoxygenase (15-Lox-2) protein and cDNA and a cDNA for mouse 8S-lipoxygenase are described. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also described, along with methods of producing each. Isolated and purified antibodies to 15-Lox-2 and 8-Lox, and methods of producing the same, are also described.


Licensing Contact

Janis Elsner

615.343.2430

Inventors

Alan Brash

EP4 Transgenic Mice

EP4 Transgenic Mice are part of the Vanderbilt Research Tools Catalog.


Licensing Contact

Karen Rufus

615.322.4295

Cell Line with Stable Expression of Human Cardiac Sodium Channel (hH1, a.k.a. hNav1.5, SCN5A)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George, Dao Wang
Research Tools
Cell Line
Cardiovascular

Cell Line with Stable Expression of Recombinant Human Skeletal Muscle Chloride Channel (hCIC-1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle chloride channel (hClC-1). The cells enable high throughput screening of compounds that modulate chloride channel activity.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Cell Line
Neuroscience/Neurology

Cell Line with Stable Expression of Human Skeletal Muscle Sodium Channel (hSkM1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle voltage-gated sodium channel (hSkMl). The cells enable high throughput screening of compounds that modulate sodium channel activity.


Licensing Contact

Karen Rufus

615.322.4295

Inventors

Alfred George
Research Tools
Cell Line

Cell Line with Stable Expression of Recombinant Human Chloride Channel, hCIC-4

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human chloride channel (hClC-4). The cells enable high throughput screening of compounds that modulate chloride channel activity.


Licensing Contact

Karen Rufus

615.322.4295
Research Tools
Cell Line