Browse Technologies

Displaying 1 - 10 of 234


Human antibodies targeting a novel flu epitope for use as a universal flu vaccine and treatment

Scientists at Vanderbilt have discovered a new class of human antibodies specific to a novel target for the detection, prevention, and treatment of influenza A viruses (IAV). Using structural characterization, they have identified a novel antigenic site on the hemagglutin (HA) head domain that may be targeted by multiple antibodies simultaneously in a non-competitive manner. They found that administration of these antibodies against an otherwise lethal challenge with viruses of H1N1, H3N2, H5N1, or H7N9 subtypes confers protection when used as prophylaxis or therapy against major IAV subtypes that are pathogenic to humans. These antibodies may prove effective as a universal influenza treatment or in the design of a universal influenza vaccine.


Licensing Contact

Jody Hankins

615.322.5907

Inventors

James Crowe, Seth Zost

Adaptive PCR: A PCR control system to overcome challenging conditions

A PCR control system to overcome challenging conditions. By directly monitoring the hybridization of fluorescently labelled L-DNA mimics of the template DNA strands and primers, it is possible to improve the efficiency of PCR in challenging conditions. This approach eliminates some of the sample preparation and trial and error that would otherwise be required for difficult sample types such as urine or other samples that contain high levels of salts.  In addition, this approach enables on-demand PCR in most any environment.


Licensing Contact

Jody Hankins

615.322.5907
Research Reagent

Steerable Needles: A Better Turning Radius with Less Tissue Damage

A team of Vanderbilt engineers and surgeons have developed a new steerable needle that can make needle based biopsy and therapy delivery more accurate. A novel flexure-based tip design provides enhanced steerability while simultaneously minimizing tissue damage. The present device is useful for almost any needle-based procedure including biopsy, thermal ablation, brachytherapy, and drug delivery.


Licensing Contact

Ashok Choudhury

615.322.2503

Fused in Sarcoma (FUS) Nuclear Translocation Inhibitors for Preventing Fibrosis

The research team has found that one of the key regulators of collagen production in fibrotic diseases is the FUS ribonucleoprotein. This protein is upregulated in fibrotic diseases leading to additional collagen formation and deposition. In order to combat FUS upregulation, a new approach to blocking nuclear translocation has been developed using an FUS targeting peptide approach.


Licensing Contact

Janis Elsner

615.343.2430
Therapeutics

Non-Invasive Skin Cancer Detection using Raman Spectroscopy-OCT System (Portfolio)

Vanderbilt University researchers have designed a system for non-invasive discrimination between normal and cancerous skin lesions. The system combines the depth-resolving capabilities of OCT technique with Raman Spectroscopy's specificity of molecular chemistry. By linking both imagining techniques into a single detector arm, the complexity, cost, and size of previously reported RS-OCT instruments have been significantly improved. The combined instrument is capable of acquiring data sets that allow for more thorough assessment of a sample than existing optical techniques.


Licensing Contact

Ashok Choudhury

615.322.2503

Systems and Methods for Optical Stimulation of Neural Tissues (Portfolio)

Vanderbilt researchers have developed a novel technique for contactless simulation of the central nervous system.  This involves the use of infrared neural stimulation (INS) to evoke the observable action potentials from neurons of the central nervous system.  While infrared neural stimulation of the peripheral nervous system was accomplished almost a decade ago, this is the first technique for infrared stimulation of the central nervous system. This technology has been protected by a portfolio of issued patents.


Licensing Contact

Ashok Choudhury

615.322.2503

Prevention of Cytokine Induced Apoptosis In Intestinal Epithelial Cells By A Probiotic Bacterium

The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn's disease or ulcerative colitis) in a subject, such as a human patient.


Licensing Contact

Janis Elsner

615.343.2430

Inventors

Brent Polk, Fang Yan
Therapeutics
Protein/Peptide
Gastrointestinal

MAESTRO: Non-Robotic Dexterous Laparoscopic Instrument with a Wrist providing seven degrees of freedom

Inventors at Vanderbilt University have developed a non-robotic dexterous laparoscopic manipulator with a wrist providing seven-degrees-of-freedom. The device has a novel user interface that intuitively maps motion of the surgeon's hands to the tool's "hands".


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Devices

Trackerless Image-Guidance Using a Surgical Microscope

Researchers at Vanderbilt have developed a new image-guided, trackerless surgical microscope system to be used in soft tissue surgeries. The current method is to use a surgical microscope along with an image-guided system. This new design eliminates the need for a separate image-guidance system; the entire guidance environment can be realized within the microscope environment.


Licensing Contact

Philip Swaney

615.322.1067

Inventors

Michael Miga

New Insect Repellants Disrupt Olfactory Cues: A Strategy for Pest Protection

A multinational research team, led by Dr. L. J. Zwiebel of Vanderbilt University, has identified new compounds with potential as insect repellents. These compounds work by capitalizing on knowledge of how insect odorant receptors detect and respond to scents. Medicinal chemistry efforts have yielded a number of novel compounds that could short-circuit the insect olfactory system, essentially by over-stimulation, to effectively mask attractive odors. These compounds could be used to repel nuisance and disease-carrying insects away from humans and animals, as well as repel agricultural pests from crops or food storage facilities. Vanderbilt University is seeking commercial partners to develop the technology for agricultural uses.


Licensing Contact

Jody Hankins

615.322.5907