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The "Potentiators to Enhance Fungicide Performance" initiative focuses on discovering novel compounds or formulations that act as potentiators for existing fungicides. Projects should aim to improve the efficacy of fungicides, reduce the required dosage, and promote sustainable disease control in various agricultural settings.
What we're looking for:
Seeking potentiators capable of delivering a "second knockout punch" by:
- Improving fungicide bioavailability
- Offering an additional mode of action
- Disabling a known resistance mechanism
- Inhibiting cellular stress responses
Specifically, the focus is on potentiators discovered through chemical library screens, which involve combining sub-lethal doses of a fungicide against either a laboratory fungal pathogen or a fungicide-resistant strain.
The aim is to collaborate on the following aspects:
- Production or synthesis of potentiator candidates
- Evaluation of efficacy when combined with proprietary fungicides, which fall within specific chemistry and mode-of-action groups
This collaboration seeks to enhance fungicide performance and provide more effective solutions for controlling fungal pathogens by working together on potentiator development and evaluation.
Must-have requirements are:
- Shows no fungicide or toxic activity independently, only in combination with a fungicide
- Reduces minimum inhibitory concentration of the fungicide in checkerboard assays
- Mode-of-action can be predicted or defined
- Can be detected and quantified using an analytical method
- Non-toxic to human cell lines
- Ability to supply a minimum of 10 mg of sample upon request
Nice-to-have requirements are:
- Non-toxic to animal models
- Viably produced via scale-up bioprocessing or chemical synthesis.
Out of scope:
- Volatile or unstable compounds.