Novel delivery platforms for OTC allergic rhinitis relief

As a global leader in consumer health, we focus on everyday wellness through a broad range of over-the-counter solutions for nutritional support and pain relief.  

Neuropathic pain arises from damage or dysfunction within the peripheral nervous system and is distinct from other forms of pain, such as pain caused by injury or inflammation. It often manifests as burning, tingling, shooting, or stabbing sensations, severely impacting quality of life. Its complexity stems from the diverse mechanisms involved, including nerve fiber damage, altered signal processing, and hypersensitivity, making it challenging to diagnose, manage, and treat effectively.

Currently, the management of neuropathic pain primarily relies on prescription medications, such as anticonvulsants, antidepressants, and topical therapies like lidocaine patches. These treatments often provide only partial relief and may be associated with significant side effects, limiting long-term use. In the over-the-counter (OTC) space, options are limited: some topical analgesics, like capsaicin creams or menthol-based products, are marketed for pain relief, but their efficacy in true neuropathic pain is modest at best.

Developing innovative OTC treatments for neuropathic pain could significantly expand access to effective symptom management, empower individuals to manage their symptoms earlier and more proactively, and create more holistic, consumer-centered solutions that better address the complexity of neuropathic pain.

What we're looking for: 

We are looking for innovative topical and systemic solutions for neuropathic pain that can be developed into effective, consumer-friendly over-the-counter (OTC) treatments, leveraging emerging science and holistic approaches.

We are also open to novel delivery methods that enhance the efficacy or tolerability of existing active compounds, such as improving the performance of ingredients like capsaicin.

Solutions of interest:

• Topical nanoemulsion systems delivering bioactives to nerves
• Wearable patches using microcurrent or transcutaneous electrical nerve stimulation
• Targeted cooling therapy devices
• Nutraceuticals supporting nerve repair
• Topical cannabinoids (e.g., CBD) formulated for neuropathic pain
• Smart wearables that monitor pain flare-ups and deliver interventions
• Vibration therapy tools designed for home-based nerve stimulation
• Microneedle patches delivering nerve-calming agents
• Multi-sensory kits combining olfactory, thermal, and tactile stimuli for nerve distraction
• Photobiomodulation (low-level light therapy) OTC devices for nerve pain relief

Must-have requirements are:

• Preliminary evidence or scientific rationale indicating potential efficacy
• Designed or adaptable for consumer-friendly, over-the-counter (OTC) use

Please note: Faculty and researchers interested in applying for these opportunities based on technologies developed or disclosed at Vanderbilt must submit their proposals through the CTTC.