Cutting-edge Technologies to Discover Cryptic Pockets and Their Modulation

A global pharmaceutical company seeks novel technologies for efficient discovery of protein drug targets with cryptic pockets and ligand discovery strategies to target these pockets. The focus is on identifying or predicting cryptic pockets themselves, with enzymes being of highest interest.

 Approaches of interest:

• Wet-based and dry-based approaches for discovering cryptic pockets
• Discovery of cryptic pockets in disease-relevant GoF or LoF mutations
• High-throughput screening methods for cryptic pocket ligand discovery
• Small molecules and peptides for targeting cryptic pockets

 Out of scope:

• Research relating to GPCRs and ion channels
• Biologics, cell therapy, gene therapy, and medical devices
• Methods using known information about cryptic pockets to discover alternative binders

Developmental stage of interest: All stages with proof-of-concept are within scope. Novel targets, assay systems, or methodologies should provide data demonstrating validity.