VUMC

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Study reveals safety signal from genes that mimic drugs

Prospective mothers taking a new class of cholesterol-lowering drugs might incur higher risk of spina bifida in their future children, according to a study published in the journal Drug Safety by researchers at Vanderbilt University Medical Center.

The first two drugs in the new class, alirocumab and evolocumab, were approved by the Food and Drug Administration in 2015. They’re taken by patients who don’t respond well to first-line therapy.


Initiative seeks to address malnutrition among adult patients

It is estimated that nearly one out of five pediatric patients and one of three adult patients age 60 and older are malnourished and will experience a decline in their nutritional status during their hospital stay.


Versatile C. difficile blocker

Clostridium difficile (C. difficile) infection is the leading cause of hospital-acquired diarrhea, causing nearly a half million infections in the United States each year. Recurrence after treatment with antibiotics is common and new therapies are needed.


Study tracks sodium-potassium pathway

A six-member group of biomedical scientists from Europe and the United States, including Eric Delpire, PhD, MS, professor of Anesthesiology, has been awarded a $6 million grant to study the role of dietary potassium in hypertension.

The five-year grant was awarded by the Paris-based Fondation LeDucq as part of its Transatlantic Networks of Excellence Program.


VUMC joins national effort to block global pandemics of potentially lethal viruses

The U.S. Defense Advanced Research Projects Agency (DARPA) has signed a five-year cooperative agreement worth up to $28 million with Vanderbilt University Medical Center (VUMC) to develop methods for preventing the global spread of viruses like chikungunya and Zika.