Research

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Endotoxin shock protector

Using a novel cell-penetrating peptide they designed and tested in mice that selectively suppresses nuclear transport through importin alpha 5, Jacek Hawiger, MD, PhD, Jozef Zienkiewicz, PhD, Yan Liu, MD, and colleagues showed that endotoxin shock is mediated by proinflammatory SRTFs rather than lipid-regulating SREBPs.


Imaging host-pathogen battle for metal

Bacterial pathogens require nutrient metals to survive and cause disease, and hosts try to protect themselves by hiding metals away — a process called “nutritional immunity.” Bacteria have evolved multiple strategies for getting the metals they need, including the secretion of small molecule metal-binding “sponges” called siderophores.


A new regulator of B cell development

The researchers detected IL-33 during early B cell development in humans and found reduced IL-33 expression in B cell chronic lymphocytic leukemia samples compared to healthy controls.


Colorectal cancer researchers receive SPORE funding

Colorectal cancer researchers from Vanderbilt-Ingram Cancer Center (VICC) have been awarded a Specialized Program of Research Excellence grant from the National Cancer Institute (NCI).