Browse Technologies

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TagDock: An Efficient Rigid Body Molecular Docking Algorithm For Three Dimensional Models of Oligomeric Biomolecular Complexes With Limited Experimental Restraint Data

TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Terry Lybrand, Jarrod Smith, Christopher Moth, Sarah Edwards
Category:
Bioinformatics Computer Science & Communications Research Tools

Lickometer: Instrument for measuring rodent drinking behavior

Researchers at Vanderbilt University designed an instrument capable of higher accuracy and analyzing lick microstructure compared to current available models. This device is compatible with classic ventilated home cages, making it easy to build and use with an intuitive touchscreen graphical user interface. The system tracks two-bottle choice licking behavior in up to 18 rodent cages, or 36 single bottles, on a minute-to-minute timescale controlled by a single Arduino microcontroller. Ultimately, the system measures drinking preference over time and changes in bout microstructure, with undisturbed recordings lasting up to 7 days.

Licensing Contact

Greg Pawel

615.343.0996

Inventors

Marie Doyle, Nicholas Petersen, Danny Winder
Category:
Research Tools
Field of Use:
Metabolic Disorders/ Diabetes

Diagnostics Management Team

The sheer volume of medical information available to physicians today is overwhelming. Diagnostic Management Team provides a concise, accurate method for ordering the correct diagnostic tests every time, and it returns the results in a uniform report format, easily read by the physician. This has already been launched within Vanderbilt University, with a high adoption rate amongst physicians and has already shown significant savings.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Mary Zutter
Category:
Diagnostics Health Care IT
Field of Use:
Oncology

Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Researchers at Vanderbilt University have developed a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses, making powerful CAR T cell therapies more accessible to patients in need.

Licensing Contact

Cameron Sargent

615.322.5907

Inventors

Michael King, Jenna Dombroski, Jacob Hope, Nicole Sarna
Category:
Research Tools Therapeutics
Field of Use:
Inflammatory/Immune/Wound Repair Oncology Oncology
Modality:
Cellular Therapy
Research Tool Type:
Cellular Therapy

One-Step Hydrosilylation for Click Chemistry Compatible Surfaces

Vanderbilt inventors have developed a one-step hydrosilylation synthesis of azide surfaces for the preparation of click chemistry compatible substrates. In this process, an organic azide is formed in a single step on a hydrogen-terminated silicon support, yielding a surface that is ready to undergo click reactions as desired. Simple, efficient, and versatile, click chemistry is widely used and is particularly useful for biosensing applications. A click reaction can be utilized to attach a molecular or biological probe for point-of-care diagnostics and chemical screening.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Bradley Baker, Paul Laibinis
Category:
Diagnostics Thin Films & Nanomaterials

PIQASO: A rigid phantom for comprehensive end-to-end evaluation of online adaptive radiotherapy systems

There is currently no radiotherapy phantom capable of quantitatively assessing all components of an online adaptive radiotherapy (online ART) system in a comprehensive end-to-end test.Represented here is a novel, rigid phantom that can simultaneously evaluate an online ART system's image acquisition, deformable image registration, contour propagation, plan re-optimization, dose calculation, and beam delivery in a single process that is robust, quantitative, and convenient.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Adam Yock, Abby Dare, Michael Price
Category:
Diagnostics Medical Devices Medical Imaging

Improved Biomanufacturing Using Biological Clock Control for High Yield/Low Cost Bioproduct

A team of researchers at Vanderbilt University has developed a method of manipulating the circadian clock of cyanobacteria. This biological manipulation is used to increase gene expression in target genes that produce biofuel and high-value bioproducts, such as pharmaceuticals and cosmetics from precursor-expressing genes. Altering the circadian rhythm in the bacteria provides an improved approach to bioproduct development on a large scale using sunlight as a zero--cost energy solution.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Carl Johnson, Yao Xu, Phillip Weyman, Qing Xu
Category:
Energy Research Tools

Inexpensive Disposable Hydro-Jet Capsule Robot for Gastric Cancer Screening in Low-Income Countries

Gastric cancer is the second leading cause of cancer death worldwide. While screening programs have had a tremendous impact on reducing mortality, the majority of cases occur in low and middle-income countries (LMIC). Typically, screening for gastric and esophageal cancer is performed using a flexible endoscope; however, endoscopy resources for these settings are traditionally limited. With the development of an inexpensive, disposable system by Vanderbilt researchers, gastroscopy and colonoscopy can be facilitated in areas hampered by a lack of access to the appropriate means.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Pietro Valdastri, Keith Obstein, Christopher Lyne, Robert Caprara, Will Jones, Alexander Vartanian, Douglas Morgan, Erdem Erdemir, Federico Campisano, Christian Di Natali, Gabriel Scozzarro, Marco Beccani
Category:
Medical Devices Medical Imaging Robotics
Field of Use:
Gastrointestinal

A Method to Obtain Uniform Radio Frequency Fields in the Body for High Field MRI

Researchers at Vanderbilt have created a new approach to produce uniform radio frequency (RF) fields in the body during high field magnetic resonance imaging (MRI). Existing high field MRI machines create non-uniform RF fields that lead to non-uniform sensitivity in the generated images, also referred to as "hot" and "cold" spots. These local variations interfere with the tissue contrast of the images that radiologists depend upon to make accurate diagnoses. By generating uniform RF fields in the body, this technology provides the benefits of high field MRI without the non-uniform RF fields.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Adam Anderson, John Gore
Category:
Medical Imaging

Early Detection of Implant Loosening

Vanderbilt University researchers have developed a new technique for identifying implantloosening. The technique utilizes the analysis of synovial fluid as an early indicator of potential loosening of orthopedic implants.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

John Martin, David Kosson
Category:
Diagnostics Medical Devices