Browse Technologies

Displaying 21 - 30 of 95

Heterogeneous catalysis of NMR Signal Amplification by Reversible Exchange(SABRE)

Vanderbilt researchers have developed heterogeneous catalysis and catalyst for the NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization process. Coupled with the researchers' development of a method to perform SABRE in aqueous solutions, this discovery could allow fully biocompatible SABRE hyperpolarization processes in water with catalyst recycling. This would allow the production of pure aqueous contrast agents requiring only parahydrogen as a consumable.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Eduard Chekmenev, Boyd Goodson, Fan Shi, Aaron Coffey
Category:
Medical Imaging

Miniature Optical Coherence Tomography Probe for Real-time Monitoring of Surgery

Vanderbilt researchers have designed a forward scanning miniature intraoperative Optical Coherence Tomography (OCT) probe that can be used for diagnostic purposes and real-time monitoring of surgery within small spaces, such as endoscopic surgery, intraocular surgery, and other microsurgery.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Karen Joos, Jin-Hui Shen, M. Hutson, John Kozub
Category:
Medical Devices Medical Imaging

Model-based Compression Correction Framework for Ultrasound

Vanderbilt researchers have developed a system that corrects for compressional effects in ultrasound data during soft tissue imaging. The system uses tracking and digitization information to detect the pose of the ultrasound probe during imaging, and then couples this information with a biomechanical model of the tissue to correct compressional effects during intraoperative imaging.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Michael Miga, Thomas Pheiffer, Dave Smith
Category:
Computer Science & Communications Medical Imaging

New Molecules Clear Chronic Infections by Disrupting Bacterial Energy Production Pathways

New compounds developed at Vanderbilt demonstrate a unique mechanism of broad spectrum activity to stymy antibacterial resistance. The compounds are particularly useful in chronic infections where long term antibiotic therapy fails, because it specifically kills "small colony variants" -- the bacteria that have developed resistance mechanisms. These compounds show promise in treating Methicillin-resistant S. aureus (MRSA), Bacillus anthracis (anthrax), and in overcoming difficult-to-treat infections in bone in cystic fibrosis patients. These compounds could be combined with new (and old) antimicrobial drugs to outwit resistant bacterial infections.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Eric Skaar, Laura Mike, Gary Sulikowski, Alex Waterson, Paul Reid
Category:
Therapeutics

NMR Signal Amplification by Reversible Exchange (SABRE) in Water

Vanderbilt researchers have developed a method to perform the Parahydrogen Induced Polarization (PHIP) based method of Signal Amplification by Reversible Exchange (SABRE) in aqueous media. This allows the resulting hyperpolarized molecules to be used for in vivo applications.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Eduard Chekmenev, Boyd Goodson, Milton Truong, Ping He, Quinn Best, Fan Shi, Kirsten Groome, Aaron Coffey, Roman Shchepin
Category:
Medical Imaging

System and Methods of Using Image-guidance for Placement of Cochlear Stimulator Devices, Drug Carrier Devices, or the Like

Vanderbilt inventors have developed and tested a device (C-in) and method that would shift the current invasive, risky surgical procedure of cochlear implantation to a less invasive outpatient procedure.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Robert Labadie, J Michael Fitzpatrick
Category:
Medical Devices Medical Imaging

Two Degrees-of-Freedom, Fluid Power Stepper Actuator Model

Vanderbilt researchers have developed a novel technology for use of a flexible fluidic actuator in MRI-guided surgical systems. This method eliminates the need for moving the patient out of the MRI machine, onto an operating table, and back in order to perform procedures. It is a safe, sterilized, and successful method to simplify MRI-guided surgical procedures.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

David Comber, Eric Barth, Jonathan Slightam, Vito Gervasi
Category:
Medical Devices Medical Imaging

TagDock: An Efficient Rigid Body Molecular Docking Algorithm For Three Dimensional Models of Oligomeric Biomolecular Complexes With Limited Experimental Restraint Data

TagDock is an efficient rigid body molecular docking algorithm that generates three-dimensional models of oligomeric biomolecular complexes in instances where there is limited experimental restraint data to guide the docking calculations. Through "distance difference analysis" TagDock additionally recommends followup experiments to further discriminate divergent (score-degenerate) clusters of TagDock's initial solution models

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Terry Lybrand, Jarrod Smith, Christopher Moth, Sarah Edwards
Category:
Bioinformatics Computer Science & Communications Research Tools

Oral administration of levocarnitine for treating Sjögren's Syndrome-associated dry eye

Sjögren's syndrome (SjS) is a common and debilitating autoimmune disease, causing dry eye symptoms ranging from discomfort to dysfunction. Vanderbilt researchers have identified orally administered levocarnitine as a novel potential therapeutic for treating this condition.

Licensing Contact

Mike Villalobos

615.322.6751

Inventors

Jill Pulley, Jillian Rhoads, Leslie Crofford
Category:
Natural Products Therapeutics
Field of Use:
Opthamology

Anti-inflammatory microparticles for sustained ocular drug delivery

Vanderbilt researchers have developed an injectable drug delivery vehicle using microparticles (MPs) that not only provide sustained cargo delivery over extended time but also play a therapeutic role themselves in reducing inflammation. This drug delivery platform can be used in treating ocular diseases such as glaucoma and traumatic optic neuropathy, as well as other inflammatory diseases throughout the body like peripheral arterial disease and osteoarthritis.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

Craig Duvall, Carlisle DeJulius, Richard d'Arcy, Tonia Rex, Sarah Naguib
Category:
Therapeutics
Field of Use:
Inflammatory/Immune/Wound Repair Opthamology