Browse Technologies

Displaying 31 - 40 of 47


Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

A research team at Vanderbilt University Mass Spectrometry Research Center has developed the Molecular Image Fusion software system, that by fusing spatial correspondence between histology and imaging mass spectrometry (IMS) measurements and cross-modality modeling, can predict ion distributions in tissue at spatial resolutions that exceed their acquisition resolution. The prediction resolution can even exceed the highest spatial resolution at which IMS can be physically measured. This software has been successfully tested on different IMS datasets and can be extended to other imaging modalities like MRI, PET, CT, profilometry, ion mobility spectroscopy, and different forms of microscopy.


Licensing Contact

Karen Rufus

615.322.4295

Non-Invasive Bacterial Identification for Acute Otitis Media using Raman Spectroscopy

Vanderbilt researchers have developed an optical-based method for real-time characterization of middle ear fluid in order to diagnose acute otitis media, also knows as a middle ear infection. The present technique allows for quick detection and identification of bacteria and can also be applied to other biological fluids in vivo.


Licensing Contact

Ashok Choudhury

615.322.2503

Non-Invasive Cell Size Detection

Vanderbilt researchers have developed a new method for using contrast enhanced MRI to non-invasively map and quantify cell size on a voxel-by-voxel basis. Using this approach, it is possible to monitor and detect diseases or treatments that alter the distribution of cell sizes such as cancer, muscular dystrophy, hepatocellular hypertrophy, and hypertrophic cardiomyopathy.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

Parahydrogen-Induced Polarizer (PHIP)

The present invention provides a PANACEA (Pneumatics Allow Nonmagnetic Actuation for Creation of Enhanced Alignment) polarizer system. This is an integrated assembly of pneumatically actuated, nonmagnetic hydraulic circuits that enable PASADENA chemicals to be efficiently stored, mixed, and reacted in close proximity or within NMR magnetic fields.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Medical Imaging

Real-time Detection of Position and Orientation of Wireless Endoscopy Capsule using Magnetic coupling

Vanderbilt researchers have developed a new system to detect the position, orientation, and pressure exerted on surrounding tissues of a wireless capsule endoscopy device.  Magnetic coupling is one of the few physical phenomena capable of transmitting actuation forces across a physical barrier.  Magnetic manipulation has the potential to make surgery less invasive, by allowing untethered miniature devices to enter the body through natural orifices or tiny incisions, and then maneuver with minimal disruption to healthy tissue.  In order to accomplish this goal, the pose (position and orientation) of the medical device must be available in real time.


Licensing Contact

Masood Machingal

615.343.3548

Relaxation Time Discriminated 1H NMR for Bone Mechanical/Fracture Property Diagnostics

Advances in modern MRI pulse sequences, including ultrashort-echo time and related MRI methods for imaging short T2 signals, have enabled clinically-practical cortical bone imaging. Researchers at the Vanderbilt University Institute of Imaging Science have developed a method of distinguishing and quantifying nuclear magnetic resonance (NMR) signals for cortical bone analysis.


Licensing Contact

Chris Harris

615.343.4433

Selective Size Imaging using Filters via Diffusion Times (SSIFT)

Vanderbilt researchers have developed a novel MRI-based method for fast, robust, and accurate imaging of biological tissue by selecting a specific cell size range (such as tumors) without the need for a contrast agent. One exciting application of this method is imaging brain metastases (BM) that are difficult to differentiate from other brain abnormalities such as radionecrosis when using existing approaches.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Junzhong Xu
Medical Imaging

pECHO: Easy to Use Smartphone App for Assisting in Transesophageal Echocardiography Exam

Transesophageal echocardiography (TEE) is a test that uses high-frequency sound waves to create images of the heart. It provides more detail that a standard echocardiogram. Vanderbilt researchers have created a software that creates an easy to follow, step-by-step procedure for a transesophageal echocardiography exam.


Licensing Contact

Masood Machingal

615.343.3548

Micro-Mirrored Pyramidal Wells

This technology is a system for 3D imaging of live biological cells fabricated using conventional semiconductor technology that provides simultaneous images from multiple vantage points.


Licensing Contact

Ashok Choudhury

615.322.2503
Medical Imaging

PANORAMIC: Precession and Nutation for Observing Rotation at Multiple Intervals about the Carrier

Methods of hyperpolarization based on parahydrogen have been expanding recently from the early applications in hydrogenation chemistry to biomedical imaging where they are expected to yield similar information as the competing technology, dynamic nuclear polarization, (DNP). These hyperpolarization experiments have already enabled the measurement of metabolism in vivo at temporal resolutions of seconds. When infused into organisms harboring tumor cells, molecules such as pyruvate and lactate have been shown to be sufficiently long-lived to infiltrate cellular metabolic cycles and be converted at different rates in cancer versus normal tissue. DNP has been used most frequently in these early studies, owing to commercial availability and the flexibility to polarize small molecules such as pyruvate and lactate. Techniques based on chemical addition or exchange of parahydrogen have also shown promise for generating metabolic contrast in vivo at similar levels of signal enhancement and at lower costs.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Medical Imaging