Vanderbilt University researchers have designed a system for non-invasive discrimination between normal and cancerous skin lesions. The system combines the depth-resolving capabilities of OCT technique with Raman Spectroscopy's specificity of molecular chemistry. By linking both imagining techniques into a single detector arm, the complexity, cost, and size of previously reported RS-OCT instruments have been significantly improved. The combined instrument is capable of acquiring data sets that allow for more thorough assessment of a sample than existing optical techniques.