Browse Technologies

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I-Wire: A Biotension Measurement Device for Tissue Engineering and Pharmacology

Vanderbilt researchers have developed an integrated system ("I-Wire") for the growth of miniature, engineered 3D cardiac or other muscle or connective tissues and their active and passive mechanical characterization. The system utilizes an inverted microscope to measure the strain when the tissue constructs are laterally displaced using a calibrated flexible cantilevered probe.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Philip Samson, Jeffrey Davidson, Stephen Koch, Veniamin Sidorov
Category:
Diagnostics Microfluidics

Organ-on-a-Chip System

Vanderbilt researchers have developed a group of microfluidic organ-on-chip devices that include perfusion controllers, microclinical analyzers, microformulators, and integrated microfluidic measurement chips. Together, these devices can measure and control multiple organ-on-chip systems in order to model the multi-organ physiology of humans.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Dmitry Markov, Lisa McCawley, John McLean, David Cliffel, Ronald Reiserer, Philip Samson, Frank Block, Kevin Parker, Daniel Levner, Donald Ingber, Geraldine Hamilton, Josue Goss, Robert Cunningham, Jennifer McKenzie, Anthony Bahinski, Christopher Hinojosa
Category:
Microfluidics

Low-cost, Normally Closed Microfluidic Valve

Vanderbilt researchers have developed a normally closed valve that is able to provide selective movement of small fluid quantities in a microfluidic device. The present microfluidic valve can be actuated using a simple rotating drivehead and mechanical support, greatly simplifying the valve design.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Dmitry Markov, Lisa McCawley, John McLean, David Cliffel, Ronald Reiserer, Philip Samson, Frank Block, Jennifer McKenzie, William Matloff, William Tidwell, Joseph Scherrer, Erik Werner, DUPE? Frank Block
Category:
Diagnostics Microfluidics

Modular and Stackable Microfluidic Devices

Vanderbilt researchers have invented a modular microfluidic bioreactor that can be layered and stacked to create complex organ-on-chip systems that mimic the behavior of human organ systems such as the neurovascular unit. This modular device can also be assembled from separate, functioning biolayers, and at the end of a study disassembled for examination of individual cellular components.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Dmitry Markov, Ronald Reiserer
Category:
Microfluidics

A Novel Organs-On-Chip Platform

Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both controlled by the intelligent use of a computer-operated system of pumps and valves. This permits, for the first time, a compact, low-cost system for creating a time-dependent drug dosage profile in a tissue system inside each well.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Frank Block, Dmitry Markov, Philip Samson, David Schaffer, Ronald Reiserer
Category:
Diagnostics Medical Devices Microfluidics Research Tools

Rotary Planar Peristaltic Micropump (RPPM) and Rotary Planar Valve (RPV) for Microfluidic Systems

A Vanderbilt University research team led by Professor John Wikswo has developed low-cost, small-volume, metering peristaltic micropumps and microvalves. These pumps and valves can be used either as stand-alone devices incorporated into microfluidic subsystems, or as readily customized components for research or miniaturized point-of-care instruments, Lab-on-a-Chip devices, and disposable fluid delivery cartridges.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

John Wikswo, Jr., Parker Gould, Lloyd (Loi) Hoang, William Matloff, Kevin Seale, Joseph Scherrer, Erica Curtis Anstett, Douglas Hall, Ayeeshik Kole, Ronald Reiserer, William Tidwell, Philip Samson, David Schaffer, Dmitry Markov
Category:
Medical Devices Microfluidics

New Optical Tweezers for Rapid Control of Nanoscale Objects

Vanderbilt researchers have developed a novel technology for trapping and dynamically manipulating nanoscale objects. Control over miniature objects like proteins can aid in applications such as biological sensing, single molecule analysis, and size-based sorting of nanoscale objects.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Justus Ndukaife
Category:
General Engineering Microfluidics