Browse Technologies

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Adaptive PCR: A PCR control system to overcome challenging conditions

A PCR control system to overcome challenging conditions. By directly monitoring the hybridization of fluorescently labelled L-DNA mimics of the template DNA strands and primers, it is possible to improve the efficiency of PCR in challenging conditions. This approach eliminates some of the sample preparation and trial and error that would otherwise be required for difficult sample types such as urine or other samples that contain high levels of salts.  In addition, this approach enables on-demand PCR in most any environment.

Licensing Contact

Karen Rufus

615.322.4295

Inventors

Frederick Haselton, Elliott Dawson, Nicholas Adams, Steve Simmons
Category:
Diagnostics Medical Devices
Field of Use:
Research Reagent

Non-Invasive Skin Cancer Detection using Raman Spectroscopy-OCT System (Portfolio)

Vanderbilt University researchers have designed a system for non-invasive discrimination between normal and cancerous skin lesions. The system combines the depth-resolving capabilities of OCT technique with Raman Spectroscopy's specificity of molecular chemistry. By linking both imagining techniques into a single detector arm, the complexity, cost, and size of previously reported RS-OCT instruments have been significantly improved. The combined instrument is capable of acquiring data sets that allow for more thorough assessment of a sample than existing optical techniques.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Anita Mahadevan-Jansen, David Dickensheets, Chetan Patil, Tom van Leeuwen, Chad Lieber, Jereon Kalkman
Category:
Diagnostics Medical Devices Medical Imaging

Systems and Methods for Optical Stimulation of Neural Tissues (Portfolio)

Vanderbilt researchers have developed a novel technique for contactless simulation of the central nervous system.  This involves the use of infrared neural stimulation (INS) to evoke the observable action potentials from neurons of the central nervous system.  While infrared neural stimulation of the peripheral nervous system was accomplished almost a decade ago, this is the first technique for infrared stimulation of the central nervous system. This technology has been protected by a portfolio of issued patents.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Eric Jansen, Anita Mahadevan-Jansen, Jonathan Cayce, Austin Duke, Peter Konrad, Jay Walsh, Robert Friedman, Agnelia Izzo, Karthikeyan Mariappan, Jonathon Wells, Claus-Peter Richter, Anna Roe, Changquing Kao, Mykyta Chernov, Charles Lemaire, James Webb, Mark Bendett
Category:
Diagnostics Medical Devices Medical Imaging Therapeutics

Wolbachia genetic tools for population control of harmful insects

Vanderbilt scientists have engineered transgenic methods for controlling the populations of insects, including infectious disease vectors like mosquitoes and agricultural pests that destroy crops and livestock.

Licensing Contact

Cameron Sargent

615.322.5907

Inventors

Sarah Bordenstein, Seth Bordenstein, Daniel LePage, Jessamyn Perlmutter, Julie Reveillaud, John (Dylan) Shropshire, Ahmet Eren, Jason Metcalf, Mark Hochstrasser, John Beckmann, Judith Ronau
Category:
Agriculture & Environment Research Tools
Field of Use:
Infectious Disease Infectious Disease Infectious Disease Infectious Disease Infectious Disease

New Insect Repellants Disrupt Olfactory Cues: A Strategy for Pest Protection

A multinational research team, led by Dr. L. J. Zwiebel of Vanderbilt University, has identified new compounds with potential as insect repellents. These compounds work by capitalizing on knowledge of how insect odorant receptors detect and respond to scents. Medicinal chemistry efforts have yielded a number of novel compounds that could short-circuit the insect olfactory system, essentially by over-stimulation, to effectively mask attractive odors. These compounds could be used to repel nuisance and disease-carrying insects away from humans and animals, as well as repel agricultural pests from crops or food storage facilities. Vanderbilt University is seeking commercial partners to develop the technology for agricultural uses.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Laurence Zwiebel, Gregory Pask, David Rinker, Patrick Jones
Category:
Agriculture & Environment Research Tools

Point of Care Rheological Assay for Sickle Cell Disease

Vanderbilt researchers have created a novel technology for the diagnosis and monitoring of disease states using the rheological properties of a blood sample with a lateral flow membrane.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Kevin Cyr, Christina Marasco, Jennifer Colby
Category:
Diagnostics Medical Devices

Trackerless Image-Guidance Using a Surgical Microscope

Researchers at Vanderbilt have developed a new image-guided, trackerless surgical microscope system to be used in soft tissue surgeries. The current method is to use a surgical microscope along with an image-guided system. This new design eliminates the need for a separate image-guidance system; the entire guidance environment can be realized within the microscope environment.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Michael Miga
Category:
Medical Devices Medical Imaging

I-Wire: A Biotension Measurement Device for Tissue Engineering and Pharmacology

Vanderbilt researchers have developed an integrated system ("I-Wire") for the growth of miniature, engineered 3D cardiac or other muscle or connective tissues and their active and passive mechanical characterization. The system utilizes an inverted microscope to measure the strain when the tissue constructs are laterally displaced using a calibrated flexible cantilevered probe.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

John Wikswo, Jr., Philip Samson, Jeffrey Davidson, Stephen Koch, Veniamin Sidorov
Category:
Diagnostics Microfluidics

PosiSeat(TM): Assured Seating of Threaded Surgical Components

Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest.

Licensing Contact

Taylor Jordan

615.936.7505

Inventors

J Michael Fitzpatrick, Robert Labadie, Jason Mitchell
Category:
Medical Devices Medical Imaging

Image Guidance System for Breast Cancer Surgery

Vanderbilt researchers have developed an image guidance system that aims to reduce the revision rate for breast conserving surgeries through the use of intraoperative tumor location. The platform integrates MRI imaging, optical tracking, tracked ultrasound, and patient specific biomechanical models to provide a superior tumor localization end result.

Licensing Contact

Philip Swaney

615.322.1067

Inventors

Michael Miga, Ingrid Meszoely, Rebekah Griesenauer, Thomas Pheiffer
Category:
Medical Devices Medical Imaging