ARF and ARF Mimics to Inhibit Myc Protein Function

Summary

The c-Myc oncogene is bound by p19Arf, which inhibits c-Myc's ability to transform cells while augmenting apoptosis. This provides the basis for screening assays that examine the ability of various candidate substances to promote p19Arf interactions, or to substitute therefor.

Patent

U.S. Patent # 7,625,716: Methods for assessing p19-Arf interactions in cMyc


Licensing Contact

Mike Villalobos

615.322.6751
Tech ID:
VU0417

Inventors

Stephen Hann
Therapeutics