A cataract-heart connection

If you’ve kept up with science-related news lately, then you’ve probably heard about CRISPR-Cas9, the latest and greatest new tool for gene editing.

Sanjay Mishra, Shu-Yu Wu, Ph.D., and colleagues led by Hassane Mchaourab, Ph.D., recently reported in the Journal of Biological Chemistry the use of CRISPR editing in zebrafish to specifically delete alpha-B crystallin genes, which play roles in maintaining lens transparency in the eye and heart muscle integrity. It was the first time both variants of these genes have been deleted in vertebrates without altering other genes.

Read the full article here.